Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: A systematic review

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Sinus bacteriology in patients with cystic fibrosis or primary ciliary dyskinesia: A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Intranasal corticosteroids compared with oral antihistamines in allergic rhinitis: A systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  3. Asthma in ear, nose, and throat primary care patients with chronic rhinosinusitis with nasal polyps

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Increased endothelin 1 type B receptors in nasal lesions of patients with granulomatosis with polyangiitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Circulating tumour DNA alterations as biomarkers for head and neck cancer: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. The current epidemic of HPV-associated oropharyngeal cancer: An 18-year Danish population-based study with 2,169 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Trends of ankyloglossia and lingual frenotomy in hospital settings among children in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. High nodal FDG uptake increases risk of distant metastasis in patients with oropharyngeal squamous cell carcinoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Ultra-high-fidelity virtual reality mastoidectomy simulation training: a randomized, controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and asthma are strongly associated, and patients suffering from both diseases are often difficult to treat. However, no guidelines about the management of patients with CRS and coexisting asthma exist.

OBJECTIVE: The purpose of this systematic review was to evaluate the management of CRSwNP and coexisting asthma.

METHODS: We systematically searched electronic databases and included clinical trials in which the clinical outcomes after medical or surgical treatment of patients with CRSwNP and asthma were assessed. The strength of the evidence for each outcome was graded on the basis of study quality and consistency in findings.

RESULTS: We included seven trials in which the effect of montelukast, omalizumab, erythromycin, and functional endoscopic sinus surgery (FESS) were studied in 317 adults with CRSwNP and asthma. All the interventions improved the majority of subjective and objective nasal outcomes significantly. However, few studies found significant effects on pulmonary function tests. The strength of the evidence was low overall.

CONCLUSION: Both FESS and medical interventions with systemic anti-inflammatory drugs improved nasal outcomes, although their efficacy in relation to the lower airways remains unclear. A low number of studies met inclusion criteria for this systematic review, which emphasizes the need for high-quality trials to explore the treatment of patients with CRSwNP and coexisting asthma.

Original languageEnglish
JournalAmerican Journal of Rhinology & Allergy
Volume29
Issue number3
Pages (from-to)193-201
Number of pages9
ISSN1945-8924
DOIs
Publication statusPublished - 16 May 2015

ID: 46001215