Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

Research output: Contribution to journalReviewResearchpeer-review

  1. Markers of bone turnover are reduced in patients with CF related diabetes; the role of glucose

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Defining antimicrobial resistance in cystic fibrosis

    Research output: Contribution to journalReviewResearchpeer-review

  5. The choice of lung function reference equation affects clinical trial eligibility: Results from a cystic fibrosis cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hydrochloric acid prolongs the lifetime of central venous catheters in haematologic patients with bacteraemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-Term Outcomes of Partial Oral Treatment of Endocarditis

    Research output: Contribution to journalLetterResearch

  4. Epidemiology of bloodstream infections in patients with chronic lymphocytic leukemia: a longitudinal nation-wide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

Original languageEnglish
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume17
Issue number2
Pages (from-to)143-152
Number of pages10
ISSN1569-1993
DOIs
Publication statusPublished - Mar 2018

ID: 56224483