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Mechanisms of humoral immune response against Pseudomonas aeruginosa biofilm infection in cystic fibrosis

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  1. The impact of chest computed tomography and chest radiography on clinical management of cystic fibrosis lung disease

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  2. Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis

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  3. Antisense oligonucleotide eluforsen is safe and improves respiratory symptoms in F508DEL cystic fibrosis

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  4. Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

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  1. Accelerated treatment of endocarditis-The POET II trial: Rationale and design of a randomized controlled trial

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  2. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

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  3. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

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P. aeruginosa chronic lung infection is the major cause of morbidity and mortality in patients with cystic fibrosis (CF), and is characterized by a biofilm mode of growth, increased levels of specific IgG antibodies and immune complex formation. However, despite being designed to combat this infection, such elevated humoral response is not associated with clinical improvement, pointing to a lack of anti-pseudomonas effectiveness. The mode of action of specific antibodies, as well as their structural features, and even the background involving B-cell production, stimulation and differentiation into antibody-producing cells in the CF airways are poorly understood. Thus, the aim of this review is to discuss studies that have addressed the intrinsic features of the humoral immune response and provide new insights regarding its insufficiency in the CF context.

Original languageEnglish
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume17
Issue number2
Pages (from-to)143-152
Number of pages10
ISSN1569-1993
DOIs
Publication statusPublished - Mar 2018

ID: 56224483