Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Aquaporin-2 membrane targeting: still a conundrum

Research output: Contribution to journalReviewResearchpeer-review

  1. Antioxidant treatment attenuates lactate production in diabetic nephropathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effects of terlipressin on the aquaretic system: evidence of antidiuretic effects.

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.

Original languageEnglish
JournalAmerican Journal of Physiology - Renal Physiology
Volume312
Issue number4
Pages (from-to)F744-F747
ISSN1931-857X
DOIs
Publication statusPublished - 1 Apr 2017

    Research areas

  • Animals, Aquaporin 2, Arginine Vasopressin, Body Water, Cell Membrane, Cyclic AMP, Epithelial Cells, Humans, Kidney Tubules, Collecting, Protein Transport, Receptors, Vasopressin, Second Messenger Systems, Water-Electrolyte Balance, Journal Article, Review

ID: 52147864