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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Changes in cerebral oxidative metabolism in patients with acute liver failure

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  1. Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity

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  2. Reduced cerebral cortical thickness in Non-cirrhotic patients with hepatitis C

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  3. Efficacy of liver assisting in patients with hepatic encephalopathy with special focus on plasma exchange

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  4. The continuous reaction times method for diagnosing, grading, and monitoring minimal/covert hepatic encephalopathy

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  5. Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema

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  1. Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

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  2. Cerebral Blood Flow and Metabolism in Hepatic Encephalopathy-A Meta-Analysis

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  3. Impaired cerebral microcirculation induced by ammonium chloride in rats is due to cortical adenosine release

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  4. Tacrolimus and Mycophenolate Mofetil as Second-Line Therapies for Pediatric Patients with Autoimmune Hepatitis

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Acute liver failure patients with a persistence of hyperammonemia are at an increased risk of intracranial hypertension due to development of brain oedema. In vitro studies of brain tissue and cell cultures that indicates that exposure to ammonium inhibits enzymatic activity in the tricarboxylic acid cycle, induces substrate depletion through marked glutamate utilization for glutamine synthesis and leads to mitochondrial dysfunction. In patients with acute liver failure cerebral microdialysis studies show a linear correlation between the lactate to pyruvate ratio and the glutamine concentration, as well as to some of the adenosine triphosphate degradation products. However, clinical observations of cerebral exchange rates of oxygen, glucose, lactate and amino acids challenge the interpretation of these findings. In this review the conflicting data of cerebral metabolism during acute liver failure is discussed.
Original languageEnglish
JournalMetabolic Brain Disease
Volume28
Issue number2
Pages (from-to)179-82
Number of pages4
ISSN0885-7490
DOIs
Publication statusPublished - Jun 2013

    Research areas

  • Amino Acids, Ammonia, Animals, Brain, Brain Chemistry, Humans, Hyperammonemia, Lactic Acid, Liver Failure, Acute, Oxidation-Reduction, Pyruvic Acid

ID: 42226124