Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Icosapent ethyl: safely reducing cardiovascular risk in adults with elevated triglycerides

Research output: Contribution to journalReviewResearchpeer-review

  1. Safety and tolerability evaluation of erenumab for the preventive treatment of migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Strategies to counter antipsychotic-associated weight gain in patients with schizophrenia

    Research output: Contribution to journalReviewResearchpeer-review

  3. An update on the drug safety of treating erectile dysfunction

    Research output: Contribution to journalReviewResearchpeer-review

  1. Predictive Importance of Blood Pressure Characteristics With Increasing Age in Healthy Men and Women: The MORGAM Project

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Postponement of cardiovascular outcomes by statin use: A systematic review and meta-analysis of randomized clinical trials

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: In patients at high cardiovascular risk, the rate of events remains elevated despite traditional, evidence-based lipid-lowering therapy. Residual hypertriglyceridemia is an important contributor to this risk. However, prior medications with triglyceride-lowering effects have not reduced adverse clinical outcomes in the statin era.

AREAS COVERED: The present review summarizes evidence and recommendations related to triglyceride-lowering therapy in the primary and secondary preventive settings. We provide an overview of findings from recent meta-analyses, important observational studies, and a detailed description of landmark trials, including the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT). We further review recommendations from current guidelines.

EXPERT OPINION: Icosapent ethyl is a stable, highly purified ethyl ester of eicosapentaenoic acid that safely and effectively reduces cardiovascular events in the contemporary setting. It is prescribed at a dose of 2 grams twice daily and is indicated in patients at high cardiovascular risk who have fasting or non-fasting triglyceride levels ≥150 mg/dl despite maximally tolerated statin treatment, or in individuals with triglyceride levels ≥500 mg/dl. Conversely, omega-3 fatty acid preparations containing a combination of eicosapentaenoic acid and docosahexaenoic acid are not indicated for reduction of cardiovascular risk and should be actively deprescribed.

Original languageEnglish
JournalExpert Opinion on Drug Safety
Pages (from-to)1-12
Number of pages12
ISSN1474-0338
DOIs
Publication statusE-pub ahead of print - 7 Sep 2021

    Research areas

  • Cardiovascular diseases, eicosapentaenoic acid, fatty acids, hypertriglyceridemia, omega-3, primary prevention, secondary prevention

ID: 66633532