Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Living with the cerebellar mutism syndrome: long-term challenges of the diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tumor miRNA expression profile is related to vestibular schwannoma growth rate

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Subdural contrast effusion during endovascular therapy: case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Response to: neurosurgical procedures performed during residency in Europe-preliminary numbers and time trends

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. S100B and brain derived neurotrophic factor in monozygotic twins with, at risk of and without affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Time from injury to arrival at the trauma centre in patients undergoing interhospital transfer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of glucose on risk of dementia: Mendelian randomisation studies in 115,875 individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Hypozincaemia may develop in critically ill patients, including those with acute brain injury in the early phase after hospital admission. The aim of this study was to investigate the prevalence of hypozincaemia after aneurysmal subarachnoid haemorrhage (aSAH) and its association with delayed cerebral ischemia and functional outcome.

METHODS: We retrospectively analysed a cohort of 384 patients with SAH admitted to the Neurointensive Care Unit at Rigshospitalet, Copenhagen, Denmark, in whom at least one measurement of plasma zinc concentration was done during the hospital stay. Hypozincaemia was defined as at least one measurement of plasma zinc below 10 μmol/L. Potential associations between hypozincaemia, demographic variables and functional outcome after aSAH were analysed in multivariable logistic regression models.

RESULTS: Hypozincaemia was observed in 67% (n = 257) of all patients and occurred within 7 days in more than 95% of all hypozincaemic patients. In a multivariable model, severe SAH (WFNS 3-5; OR 4.2, CI 2.21-8.32, p < 0.001) and Sequential Organ Failure Assessment (SOFA) score on the day of admission (OR 1.24, CI 1.11-1.40, p < 0.001) were independently associated with hypozincaemia. In another multivariable model, hypozincaemia was independently associated with an unfavourable outcome (defined as a modified Rankin Scale score from 3 to 6) (OR 1.97, CI 1.06-3.68, p = 0.032), as was age (OR 1.03, CI 1.01-1.05, p = 0.015), SOFA score on the day of admission (OR 1.14, CI 1.02-1.29, p = 0.02), a diagnosis of delayed cerebral ischaemia (OR 4.06, CI 2.29-7.31, p < 0.001) and a clinical state precluding assessment for delayed cerebral ischaemia (OR 15.13, CI 6.59-38.03, p < 0.001).

CONCLUSION: Hypozincaemia occurs frequently after aSAH, is associated with a higher disease severity and independently contributes to an unfavourable outcome.

Original languageEnglish
JournalActa Neurochirurgica
Volume162
Issue number6
Pages (from-to)1417-1424
Number of pages8
ISSN0001-6268
DOIs
Publication statusPublished - Jun 2020

ID: 60069043