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Hyperpolarized singlet NMR on a small animal imaging system

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  1. Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

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  2. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI

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  3. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

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  4. Comparison of prospective head motion correction with NMR field probes and an optical tracking system

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  5. Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

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  1. High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes

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  2. Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

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  3. Calibrated Coil Combination for Fixed-Geometry, Low-Frequency Coils with Application to Hyperpolarized 13C Measurements

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  4. Data-driven Nyquist ghost correction for hyperpolarized 13C EPSI and EPI

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  5. Development of a Symmetric Echo-Planar Spectroscopy Imaging Framework for Hyperpolarized 13C Imaging in a Clinical PET/MR Scanner

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Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized (13) C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume68
Issue number4
Pages (from-to)1262-5
Number of pages4
ISSN0740-3194
DOIs
Publication statusPublished - Oct 2012

ID: 36423908