Hypercoagulability in response to elevated body temperature and central hypovolemia

Martin Meyer; Sisse R Ostrowski; Flemming Anders Overgaard; Matthew S Ganio; Niels H Secher; Craig G Crandall; Pär I Johansson

doi:10.1016/j.jss.2013.06.012

Hypercoagulability in response to elevated body temperature and central hypovolemia

Martin Meyer, Sisse R Ostrowski, Flemming Anders Overgaard, Matthew S Ganio, Niels H Secher, Craig G Crandall, Pär I Johansson

Department of Clinical Immunology

30 Citations (Scopus)

Abstract

Coagulation abnormalities contribute to poor outcomes in critically ill patients. In trauma patients exposed to a hot environment, a systemic inflammatory response syndrome, elevated body temperature, and reduced central blood volume occur in parallel with changes in hemostasis and endothelial damage. The objective of this study was to evaluate whether experimentally elevated body temperature and reduced central blood volume (CBV) per se affects hemostasis and endothelial activation.

Original language	English
Journal	The Journal of surgical research
Volume	185
Issue number	2
Pages (from-to)	93-100
Number of pages	8
DOIs	https://doi.org/10.1016/j.jss.2013.06.012
Publication status	Published - 29 Jun 2013

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10.1016/j.jss.2013.06.012

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abstract = "Coagulation abnormalities contribute to poor outcomes in critically ill patients. In trauma patients exposed to a hot environment, a systemic inflammatory response syndrome, elevated body temperature, and reduced central blood volume occur in parallel with changes in hemostasis and endothelial damage. The objective of this study was to evaluate whether experimentally elevated body temperature and reduced central blood volume (CBV) per se affects hemostasis and endothelial activation.",

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AU - Meyer, Martin

AU - Ostrowski, Sisse R

AU - Overgaard, Flemming Anders

AU - Ganio, Matthew S

AU - Secher, Niels H

AU - Crandall, Craig G

AU - Johansson, Pär I

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AB - Coagulation abnormalities contribute to poor outcomes in critically ill patients. In trauma patients exposed to a hot environment, a systemic inflammatory response syndrome, elevated body temperature, and reduced central blood volume occur in parallel with changes in hemostasis and endothelial damage. The objective of this study was to evaluate whether experimentally elevated body temperature and reduced central blood volume (CBV) per se affects hemostasis and endothelial activation.

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DO - 10.1016/j.jss.2013.06.012

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EP - 100

JO - The Journal of surgical research

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Hypercoagulability in response to elevated body temperature and central hypovolemia

Abstract

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