Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

Marianne Juhler; Torben Skovbo Hansen; Hans V G Novrup; Nanna MacAulay; Tina Nørgaard Munch

doi:10.1016/j.wneu.2021.12.100

Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

Marianne Juhler, Torben Skovbo Hansen, Hans V G Novrup, Nanna MacAulay, Tina Nørgaard Munch

Department of Neurosurgery

Abstract

In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).

Original language	English
Journal	World Neurosurgery
Volume	161
Pages (from-to)	424-431
Number of pages	8
ISSN	1878-8750
DOIs	https://doi.org/10.1016/j.wneu.2021.12.100
Publication status	Published - May 2022

Keywords

ETV
Genetics
Hydrocephalus
Molecular mechanisms
Shunt
Translational research

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10.1016/j.wneu.2021.12.100

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abstract = "In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).",

keywords = "ETV, Genetics, Hydrocephalus, Molecular mechanisms, Shunt, Translational research",

author = "Marianne Juhler and Hansen, \{Torben Skovbo\} and Novrup, \{Hans V G\} and Nanna MacAulay and Munch, \{Tina N{\o}rgaard\}",

year = "2022",

month = may,

doi = "10.1016/j.wneu.2021.12.100",

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AU - MacAulay, Nanna

AU - Munch, Tina Nørgaard

PY - 2022/5

Y1 - 2022/5

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AB - In this article, we aimed to describe some of the currently most challenging problems in neurosurgical management of hydrocephalus and how these can be reasons for inspiration for and development of research. We chose 4 areas of focus: 2 dedicated to improvement of current treatments (shunt implant surgery and endoscopic hydrocephalus surgery) and 2 dedicated to emerging future treatment principles (molecular mechanisms of cerebrospinal fluid secretion and hydrocephalus genetics).

KW - ETV

KW - Genetics

KW - Hydrocephalus

KW - Molecular mechanisms

KW - Shunt

KW - Translational research

UR - https://www.scopus.com/pages/publications/85129355352

U2 - 10.1016/j.wneu.2021.12.100

DO - 10.1016/j.wneu.2021.12.100

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JO - World Neurosurgery

JF - World Neurosurgery

ER -

Hydrocephalus Study Design: Testing New Hypotheses in Clinical Studies and Bench-to-Bedside Research

Abstract

Keywords

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