Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients

Lars Peters; Amanda Mocroft; Vincent Soriano; Jürgen Rockstroh; Andri Rauch; Anders Karlsson; Brygida Knysz; Christian Pradier; Kai Zilmer; Jens D Lundgren; for EuroSIDA in EuroCoord

doi:10.1371/journal.pone.0064283

Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients

Lars Peters, Amanda Mocroft, Vincent Soriano, Jürgen Rockstroh, Andri Rauch, Anders Karlsson, Brygida Knysz, Christian Pradier, Kai Zilmer, Jens D Lundgren, for EuroSIDA in EuroCoord

24 Citations (Scopus)

Abstract

Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.

Original language	English
Journal	P L o S One
Volume	8
Issue number	5
Pages (from-to)	e64283
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0064283
Publication status	Published - 2013

Keywords

Adult
Biological Markers
Coinfection
Disease Progression
Female
Follow-Up Studies
HIV Infections
Hepatic Encephalopathy
Hepatitis, Viral, Human
Humans
Hyaluronic Acid
Incidence
Male
Middle Aged
Prognosis
Prospective Studies
ROC Curve
Risk Assessment
Young Adult

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10.1371/journal.pone.0064283

Cite this

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abstract = "Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.",

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T1 - Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients

AU - Peters, Lars

AU - Mocroft, Amanda

AU - Soriano, Vincent

AU - Rockstroh, Jürgen

AU - Rauch, Andri

AU - Karlsson, Anders

AU - Knysz, Brygida

AU - Pradier, Christian

AU - Zilmer, Kai

AU - Lundgren, Jens D

AU - for EuroSIDA in EuroCoord

PY - 2013

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N2 - Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.

AB - Whereas it is well established that various soluble biomarkers can predict level of liver fibrosis, their ability to predict liver-related clinical outcomes is less clearly established, in particular among HIV/viral hepatitis co-infected persons. We investigated plasma hyaluronic acid's (HA) ability to predict risk of liver-related events (LRE; hepatic coma or liver-related death) in the EuroSIDA study.

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KW - Biological Markers

KW - Coinfection

KW - Disease Progression

KW - Female

KW - Follow-Up Studies

KW - HIV Infections

KW - Hepatic Encephalopathy

KW - Hepatitis, Viral, Human

KW - Humans

KW - Hyaluronic Acid

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - ROC Curve

KW - Risk Assessment

KW - Young Adult

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JO - P L o S One

JF - P L o S One

IS - 5

ER -

Hyaluronic acid levels predict risk of hepatic encephalopathy and liver-related death in HIV/viral hepatitis coinfected patients

Abstract

Keywords

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