Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study

Lars Peters; Jacqueline Neuhaus; Amanda Mocroft; Vincent Soriano; Jürgen Rockstroh; Gregory Dore; Massimo Puoti; Ellen Tedaldi; Bonaventura Clotet; Bernd Kupfer; Jens D Lundgren; Marina B Klein; SMART Study Group

doi:10.3851/IMP1815

Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study

Lars Peters, Jacqueline Neuhaus, Amanda Mocroft, Vincent Soriano, Jürgen Rockstroh, Gregory Dore, Massimo Puoti, Ellen Tedaldi, Bonaventura Clotet, Bernd Kupfer, Jens D Lundgren, Marina B Klein, SMART Study Group

15 Citations (Scopus)

Abstract

In the SMART study, HIV-viral-hepatitis-coinfected persons were, compared with HIV-monoinfected persons, at higher risk of non-AIDS death if randomized to the antiretroviral therapy (ART) interruption strategy. We hypothesized that a marker of liver fibrosis, hyaluronic acid (HA), would be predictive of development of non-AIDS-related outcomes in coinfected participants in the SMART study.

Original language	English
Journal	Antiviral Therapy
Volume	16
Issue number	5
Pages (from-to)	667-75
Number of pages	9
ISSN	1359-6535
DOIs	https://doi.org/10.3851/IMP1815
Publication status	Published - 1 Jan 2011

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Peters, L., Neuhaus, J., Mocroft, A., Soriano, V., Rockstroh, J., Dore, G., Puoti, M., Tedaldi, E., Clotet, B., Kupfer, B., Lundgren, J. D., Klein, M. B., & SMART Study Group (2011). Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study. Antiviral Therapy, 16(5), 667-75. https://doi.org/10.3851/IMP1815

Peters, L, Neuhaus, J, Mocroft, A, Soriano, V, Rockstroh, J, Dore, G, Puoti, M, Tedaldi, E, Clotet, B, Kupfer, B, Lundgren, JD, Klein, MB & SMART Study Group 2011, 'Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study', Antiviral Therapy, vol. 16, no. 5, pp. 667-75. https://doi.org/10.3851/IMP1815

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abstract = "In the SMART study, HIV-viral-hepatitis-coinfected persons were, compared with HIV-monoinfected persons, at higher risk of non-AIDS death if randomized to the antiretroviral therapy (ART) interruption strategy. We hypothesized that a marker of liver fibrosis, hyaluronic acid (HA), would be predictive of development of non-AIDS-related outcomes in coinfected participants in the SMART study.",

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AU - Soriano, Vincent

AU - Rockstroh, Jürgen

AU - Dore, Gregory

AU - Puoti, Massimo

AU - Tedaldi, Ellen

AU - Clotet, Bonaventura

AU - Kupfer, Bernd

AU - Lundgren, Jens D

AU - Klein, Marina B

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AB - In the SMART study, HIV-viral-hepatitis-coinfected persons were, compared with HIV-monoinfected persons, at higher risk of non-AIDS death if randomized to the antiretroviral therapy (ART) interruption strategy. We hypothesized that a marker of liver fibrosis, hyaluronic acid (HA), would be predictive of development of non-AIDS-related outcomes in coinfected participants in the SMART study.

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Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study

Abstract

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