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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Humoral and cellular CMV responses in healthy donors; identification of a frequent population of CMV-specific, CD4+ T cells in seronegative donors

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CMV status is an important risk factor in immune compromised patients. In hematopoeitic cell transplantations (HCT), both donor and recipient are tested routinely for CMV status by serological assays; however, one might argue that it might also be of relevance to examine CMV status by cellular (i.e., T lymphocyte) assays. Here, we have analyzed the CMV status of 100 healthy blood bank donors using both serology and cellular assays. About half (56%) were found to be CMV seropositive, and they all mounted strong CD8+ and/or moderate CD4+ T cell responses ex vivo against the immunodominant CMV protein, pp65. Of the 44 seronegative donors, only five (11%) mounted ex vivo T cell responses; surprisingly, 33 (75%) mounted strong CD4+ T cell responses after a brief in vitro peptide stimulation culture. This may have significant implications for the analysis and selection of HCT donors.
Original languageEnglish
JournalP L o S One
Volume7
Issue number2
Pages (from-to)e31420
ISSN1932-6203
DOIs
Publication statusPublished - 2012

    Research areas

  • CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cytomegalovirus, Cytomegalovirus Infections, Humans, Immunity, Cellular, Immunity, Humoral, Phosphoproteins, Tissue Donors, Viral Matrix Proteins

ID: 36546242