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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Human parallels to experimental myopia? A literature review on visual deprivation

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  1. Development and validation of a multiple-choice questionnaire-based theoretical test in direct ophthalmoscopy

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  2. Visual acuity and amblyopia prevalence in 11- to 12-year-old Danish children from the Copenhagen Child Cohort 2000

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  3. Macular perfusion velocities in the ocular ischaemic syndrome

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  4. Ophthalmic nepafenac use in the Netherlands and Denmark

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  1. Recurrent, Activating Variants in the Receptor Tyrosine Kinase DDR2 Cause Warburg-Cinotti Syndrome

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  2. Ophthalmic findings in linear scleroderma manifesting as facial en coup de sabre

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  3. The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management

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  4. Early postnatal hyperglycaemia is a risk factor for treatment-demanding retinopathy of prematurity

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Raviola and Wiesel's monkey eyelid suture studies of the 1970s laid the cornerstone for the experimental myopia science undertaken since then. The aim has been to clarify the basic humoral and neuronal mechanisms behind induced myopization, its eye tissue transmitters in particular. Besides acquiring new and basic knowledge, the practical object of the research is to reduce the burden of human myopia around the world. Acquisition and cost of optical correction is one issue, but associated morbidity counts more, with its global load of myopia-associated visual loss and blindness. The object of the present PubMed literature-based review is to evaluate apparent similarities between experience from disturbed imaging in experimental laboratory science and varieties within the spectrum of childhood human myopia. So far, the main impression is that macroscopical optical deprivation appears absent in the prevalent types of human myopia, nor is myopia a regular sequel where early eye pathology has led to poor imaging and optical deprivation. Optical aberrations of a higher order are a relatively new issue in myopia research, and microstructural deprivation is only marginally dealt within the survey. Links between experimental and human myopia appear mainly occasional, and with only few examples in humans where factual parallels appear credible. Clinical and epidemiological data on refraction remain important, in particular with a view to life style and environmental factors. Such knowledge may further serve as inspiration to the laboratory research, which aims at solving the basic enigmas on a tissue level.

Original languageEnglish
JournalActa Ophthalmologica (Online)
Volume92
Issue number8
Pages (from-to)724-9
Number of pages6
ISSN1755-3768
DOIs
Publication statusPublished - Dec 2014

ID: 44851394