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Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review

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Bonde, J, Bottari, F, Iacobone, AD, Cocuzza, CE, Sandri, M-T, Bogliatto, F, Khan, KS, Ejegod, DM, Gary, DS & Andrews, JC 2021, 'Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review', Journal of lower genital tract disease, vol. 25, no. 1, pp. 27-37. https://doi.org/10.1097/LGT.0000000000000573

APA

Bonde, J., Bottari, F., Iacobone, A. D., Cocuzza, C. E., Sandri, M-T., Bogliatto, F., Khan, K. S., Ejegod, D. M., Gary, D. S., & Andrews, J. C. (2021). Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review. Journal of lower genital tract disease, 25(1), 27-37. https://doi.org/10.1097/LGT.0000000000000573

CBE

MLA

Vancouver

Author

Bonde, Jesper ; Bottari, Fabio ; Iacobone, Anna D ; Cocuzza, Clementina E ; Sandri, Maria-Teresa ; Bogliatto, Fabrizio ; Khan, Khalid S ; Ejegod, Ditte M ; Gary, Devin S ; Andrews, Jeffrey C. / Human Papillomavirus Same Genotype Persistence and Risk : A Systematic Review. In: Journal of lower genital tract disease. 2021 ; Vol. 25, No. 1. pp. 27-37.

Bibtex

@article{f32cd0c0079441968812b1bc25d951bf,
title = "Human Papillomavirus Same Genotype Persistence and Risk: A Systematic Review",
abstract = "OBJECTIVE: The aim of the study was to examine whether high-grade cervical intraepithelial neoplasia (CIN) was more closely associated with human papillomavirus (HPV) same-genotype persistence (SGTP) versus clearance of prior infection with a subsequent infection by a new genotype (genotype switch [GS]), clearance of HPV infection, or acquisition of a new HPV infection after a negative infection status, during a follow-up testing subsequent to abnormal screening results.MATERIALS AND METHODS: MEDLINE, Cochrane Library, Health Technology Assessment, and clinicaltrials.gov were searched from January 2000 to July 2019 for prospective controlled trials and observational studies of women and retrospective studies using HPV assays with extended- or full-genotype reporting. The primary outcome was high-grade CIN after at least 2 rounds of testing. Overall quality of evidence for the risk estimate outcomes was assessed. Of the 830 identified abstracts, 66 full-text articles were reviewed, and 7 studies were included in the synthesis. The study protocol was registered with the PROSPERO International Prospective Register of Systematic Reviews (CRD42018091093).RESULTS: Continued HPV-positive women falls in 2 equally large groups: SGTP and GS. Sensitivity, positive predictive value, and positive likelihood ratio of SGTP were significantly higher than for GS. Human papillomavirus genotypes may be ranked into 3 tiers (immediate colposcopy, follow-up testing, return to routine screening), according to associated risk of persistence for high-grade CIN and to prevailing clinical action thresholds.CONCLUSIONS: There is moderately high-quality evidence to support the clinical utility of SGTP to improve risk discrimination for high-grade CIN compared with qualitative HPV testing without genotype-specific information.",
keywords = "HPV, HPV genotyping, cervical cancer screening, systematic review, triage",
author = "Jesper Bonde and Fabio Bottari and Iacobone, {Anna D} and Cocuzza, {Clementina E} and Maria-Teresa Sandri and Fabrizio Bogliatto and Khan, {Khalid S} and Ejegod, {Ditte M} and Gary, {Devin S} and Andrews, {Jeffrey C}",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASCCP.",
year = "2021",
month = jan,
day = "1",
doi = "10.1097/LGT.0000000000000573",
language = "English",
volume = "25",
pages = "27--37",
journal = "Journal of Lower Genital Tract Disease",
issn = "1089-2591",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Human Papillomavirus Same Genotype Persistence and Risk

T2 - A Systematic Review

AU - Bonde, Jesper

AU - Bottari, Fabio

AU - Iacobone, Anna D

AU - Cocuzza, Clementina E

AU - Sandri, Maria-Teresa

AU - Bogliatto, Fabrizio

AU - Khan, Khalid S

AU - Ejegod, Ditte M

AU - Gary, Devin S

AU - Andrews, Jeffrey C

N1 - Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASCCP.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - OBJECTIVE: The aim of the study was to examine whether high-grade cervical intraepithelial neoplasia (CIN) was more closely associated with human papillomavirus (HPV) same-genotype persistence (SGTP) versus clearance of prior infection with a subsequent infection by a new genotype (genotype switch [GS]), clearance of HPV infection, or acquisition of a new HPV infection after a negative infection status, during a follow-up testing subsequent to abnormal screening results.MATERIALS AND METHODS: MEDLINE, Cochrane Library, Health Technology Assessment, and clinicaltrials.gov were searched from January 2000 to July 2019 for prospective controlled trials and observational studies of women and retrospective studies using HPV assays with extended- or full-genotype reporting. The primary outcome was high-grade CIN after at least 2 rounds of testing. Overall quality of evidence for the risk estimate outcomes was assessed. Of the 830 identified abstracts, 66 full-text articles were reviewed, and 7 studies were included in the synthesis. The study protocol was registered with the PROSPERO International Prospective Register of Systematic Reviews (CRD42018091093).RESULTS: Continued HPV-positive women falls in 2 equally large groups: SGTP and GS. Sensitivity, positive predictive value, and positive likelihood ratio of SGTP were significantly higher than for GS. Human papillomavirus genotypes may be ranked into 3 tiers (immediate colposcopy, follow-up testing, return to routine screening), according to associated risk of persistence for high-grade CIN and to prevailing clinical action thresholds.CONCLUSIONS: There is moderately high-quality evidence to support the clinical utility of SGTP to improve risk discrimination for high-grade CIN compared with qualitative HPV testing without genotype-specific information.

AB - OBJECTIVE: The aim of the study was to examine whether high-grade cervical intraepithelial neoplasia (CIN) was more closely associated with human papillomavirus (HPV) same-genotype persistence (SGTP) versus clearance of prior infection with a subsequent infection by a new genotype (genotype switch [GS]), clearance of HPV infection, or acquisition of a new HPV infection after a negative infection status, during a follow-up testing subsequent to abnormal screening results.MATERIALS AND METHODS: MEDLINE, Cochrane Library, Health Technology Assessment, and clinicaltrials.gov were searched from January 2000 to July 2019 for prospective controlled trials and observational studies of women and retrospective studies using HPV assays with extended- or full-genotype reporting. The primary outcome was high-grade CIN after at least 2 rounds of testing. Overall quality of evidence for the risk estimate outcomes was assessed. Of the 830 identified abstracts, 66 full-text articles were reviewed, and 7 studies were included in the synthesis. The study protocol was registered with the PROSPERO International Prospective Register of Systematic Reviews (CRD42018091093).RESULTS: Continued HPV-positive women falls in 2 equally large groups: SGTP and GS. Sensitivity, positive predictive value, and positive likelihood ratio of SGTP were significantly higher than for GS. Human papillomavirus genotypes may be ranked into 3 tiers (immediate colposcopy, follow-up testing, return to routine screening), according to associated risk of persistence for high-grade CIN and to prevailing clinical action thresholds.CONCLUSIONS: There is moderately high-quality evidence to support the clinical utility of SGTP to improve risk discrimination for high-grade CIN compared with qualitative HPV testing without genotype-specific information.

KW - HPV

KW - HPV genotyping

KW - cervical cancer screening

KW - systematic review

KW - triage

UR - http://www.scopus.com/inward/record.url?scp=85098179486&partnerID=8YFLogxK

U2 - 10.1097/LGT.0000000000000573

DO - 10.1097/LGT.0000000000000573

M3 - Review

C2 - 33105450

VL - 25

SP - 27

EP - 37

JO - Journal of Lower Genital Tract Disease

JF - Journal of Lower Genital Tract Disease

SN - 1089-2591

IS - 1

ER -

ID: 61112281