Abstract
Colorectal cancer (CRC) patients have increased levels of human neutrophil peptides 1-3 (HNP1-3) in tumour tissue and plasma. The aim is to study whether the amount of HNP1-3 in tumour and plasma from CRC patients correlate with Dukes' stages A-D. The amount of HNP1-3 in tumour tissue, normal colonic mucosa, and plasma was determined with mass spectrometry. Plasma levels of HNP1-3 were determined with enzyme-linked immuno-sorbent assay (ELISA). The amount of HNP1-3 determined with mass spectrometry was increased in tumours compared to normal colonic tissue in CRC patients in Dukes' stage A-D, whereas HNP1-3 in plasma was only elevated in Dukes' stage D compared to healthy individuals. HNP1-3 plasma concentration determined with ELISA was increased in Dukes' stages C and D, but not in A and B. It is concluded that HNP1-3 is a potential marker for prognostic assessment, surveillance of patients, and monitoring chemotherapy in CRC patients with advanced disease.
| Original language | English |
|---|---|
| Journal | European journal of cancer (Oxford, England : 1990) |
| Volume | 42 |
| Issue number | 17 |
| Pages (from-to) | 3057-64 |
| Number of pages | 8 |
| ISSN | 0959-8049 |
| DOIs | |
| Publication status | Published - Nov 2006 |
| Externally published | Yes |
Keywords
- Adult
- Biomarkers, Tumor
- Colorectal Neoplasms
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- alpha-Defensins
- Journal Article
- Research Support, Non-U.S. Gov't