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Human models of migraine - short-term pain for long-term gain

Research output: Contribution to journalReviewResearchpeer-review

  1. Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP

    Research output: Contribution to journalReviewResearchpeer-review

  2. Diagnosis and management of migraine in ten steps

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  3. MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice

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  4. Calcitonin gene-related peptide - beyond migraine prophylaxis

    Research output: Contribution to journalComment/debateResearchpeer-review

  5. Ageing as a risk factor for neurodegenerative disease

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  1. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The chronobiology of migraine: a systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  3. PEARL study protocol: a real-world study of fremanezumab effectiveness in patients with chronic or episodic migraine

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

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  5. Erenumab prevents the occurrence of migraine attacks and not just migraine days: Post-hoc analyses of a phase III study

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Migraine is a complex disorder characterized by recurrent episodes of headache, and is one of the most prevalent and disabling neurological disorders. A key feature of migraine is that various factors can trigger an attack, and this phenomenon provides a unique opportunity to investigate disease mechanisms by experimentally inducing migraine attacks. In this Review, we summarize the existing experimental models of migraine in humans, including those that exploit nitric oxide, histamine, neuropeptide and prostaglandin signalling. We describe the development and use of these models in the discovery of molecular pathways that are responsible for initiation of migraine attacks. Combining experimental human models with advanced imaging techniques might help to identify biomarkers of migraine, and in the ongoing search for new and better migraine treatments, human models will have a key role in the discovery of future targets for more-specific and more-effective mechanism-based antimigraine drugs.

Original languageEnglish
JournalNature reviews. Neurology
Volume13
Issue number12
Pages (from-to)713-724
Number of pages12
ISSN1759-4758
DOIs
Publication statusPublished - Dec 2017

    Research areas

  • Journal Article, Review

ID: 52191965