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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Human models of migraine - short-term pain for long-term gain

Research output: Contribution to journalReviewResearchpeer-review

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  4. The changing faces of migraine

    Research output: Contribution to journalEditorialResearchpeer-review

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Migraine is a complex disorder characterized by recurrent episodes of headache, and is one of the most prevalent and disabling neurological disorders. A key feature of migraine is that various factors can trigger an attack, and this phenomenon provides a unique opportunity to investigate disease mechanisms by experimentally inducing migraine attacks. In this Review, we summarize the existing experimental models of migraine in humans, including those that exploit nitric oxide, histamine, neuropeptide and prostaglandin signalling. We describe the development and use of these models in the discovery of molecular pathways that are responsible for initiation of migraine attacks. Combining experimental human models with advanced imaging techniques might help to identify biomarkers of migraine, and in the ongoing search for new and better migraine treatments, human models will have a key role in the discovery of future targets for more-specific and more-effective mechanism-based antimigraine drugs.

Original languageEnglish
JournalNature reviews. Neurology
Volume13
Issue number12
Pages (from-to)713-724
Number of pages12
ISSN1759-4758
DOIs
Publication statusPublished - Dec 2017

    Research areas

  • Journal Article, Review

ID: 52191965