Human leukocyte antigen system associations in Malassezia-related skin diseases

P Lindsø Andersen; G B Jemec; C Erikstrup; M Didriksen; K M Dinh; S Mikkelsen; E Sørensen; K R Nielsen; M T Bruun; H Hjalgrim; T F Hansen; S G Sækmose; S R Ostrowski; D M L Saunte; O B Pedersen; DBDS Genetic Consortium

doi:10.1007/s00403-022-02454-9

Human leukocyte antigen system associations in Malassezia-related skin diseases

P Lindsø Andersen^*, G B Jemec, C Erikstrup, M Didriksen, K M Dinh, S Mikkelsen, E Sørensen, K R Nielsen, M T Bruun, H Hjalgrim, T F Hansen, S G Sækmose, S R Ostrowski, D M L Saunte, O B Pedersen, DBDS Genetic Consortium

^*Corresponding author for this work

1 Citation (Scopus)

Abstract

BACKGROUND: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD.

MATERIALS AND METHODS: Participants in The Danish Blood Donor Study (2010-2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests.

RESULTS: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09-1.31), C*01:02, OR 1.19 (95% CI: 1.08-1.32), C*06:02, OR 1.14 (95% CI: 1.08-1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04-1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85-0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85-0.94).

CONCLUSION: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.

Original language	English
Journal	Archives of Dermatological Research
Volume	315
Issue number	4
Pages (from-to)	895-902
Number of pages	8
ISSN	0340-3696
DOIs	https://doi.org/10.1007/s00403-022-02454-9
Publication status	Published - May 2023

Keywords

Blood donors
Head and neck dermatitis
Major histocompatibility complex
Malassezia folliculitis
Pityriasis versicolor
Seborrheic dermatitis
Dermatomycoses/blood
Humans
Middle Aged
Genotype
Male
Skin Diseases, Genetic
HLA Antigens/genetics
Case-Control Studies
Malassezia/genetics
Blood Donors
Alleles
Denmark
Adult
Female
Cohort Studies

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Lindsø Andersen, P., Jemec, G. B., Erikstrup, C., Didriksen, M., Dinh, K. M., Mikkelsen, S., Sørensen, E., Nielsen, K. R., Bruun, M. T., Hjalgrim, H., Hansen, T. F., Sækmose, S. G., Ostrowski, S. R., Saunte, D. M. L., Pedersen, O. B., & DBDS Genetic Consortium (2023). Human leukocyte antigen system associations in Malassezia-related skin diseases. Archives of Dermatological Research, 315(4), 895-902. https://doi.org/10.1007/s00403-022-02454-9

Lindsø Andersen, P, Jemec, GB, Erikstrup, C, Didriksen, M, Dinh, KM, Mikkelsen, S, Sørensen, E, Nielsen, KR, Bruun, MT, Hjalgrim, H, Hansen, TF, Sækmose, SG, Ostrowski, SR, Saunte, DML, Pedersen, OB & DBDS Genetic Consortium 2023, 'Human leukocyte antigen system associations in Malassezia-related skin diseases', Archives of Dermatological Research, vol. 315, no. 4, pp. 895-902. https://doi.org/10.1007/s00403-022-02454-9

@article{2fec5543a4874e45af7a8ff2866de603,

title = "Human leukocyte antigen system associations in Malassezia-related skin diseases",

abstract = "BACKGROUND: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD.MATERIALS AND METHODS: Participants in The Danish Blood Donor Study (2010-2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests.RESULTS: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09-1.31), C*01:02, OR 1.19 (95% CI: 1.08-1.32), C*06:02, OR 1.14 (95% CI: 1.08-1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04-1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85-0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85-0.94).CONCLUSION: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.",

keywords = "Blood donors, Head and neck dermatitis, Major histocompatibility complex, Malassezia folliculitis, Pityriasis versicolor, Seborrheic dermatitis, Dermatomycoses/blood, Humans, Middle Aged, Genotype, Male, Skin Diseases, Genetic, HLA Antigens/genetics, Case-Control Studies, Malassezia/genetics, Blood Donors, Alleles, Denmark, Adult, Female, Cohort Studies",

author = "{Linds{\o} Andersen}, P and Jemec, {G B} and C Erikstrup and M Didriksen and Dinh, {K M} and S Mikkelsen and E S{\o}rensen and Nielsen, {K R} and Bruun, {M T} and H Hjalgrim and Hansen, {T F} and S{\ae}kmose, {S G} and Ostrowski, {S R} and Saunte, {D M L} and Pedersen, {O B} and {DBDS Genetic Consortium}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2023",

month = may,

doi = "10.1007/s00403-022-02454-9",

language = "English",

volume = "315",

pages = "895--902",

journal = "Archives of Dermatological Research",

issn = "0340-3696",

publisher = "Springer",

number = "4",

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TY - JOUR

T1 - Human leukocyte antigen system associations in Malassezia-related skin diseases

AU - Lindsø Andersen, P

AU - Jemec, G B

AU - Erikstrup, C

AU - Didriksen, M

AU - Dinh, K M

AU - Mikkelsen, S

AU - Sørensen, E

AU - Nielsen, K R

AU - Bruun, M T

AU - Hjalgrim, H

AU - Hansen, T F

AU - Sækmose, S G

AU - Ostrowski, S R

AU - Saunte, D M L

AU - Pedersen, O B

AU - DBDS Genetic Consortium

PY - 2023/5

Y1 - 2023/5

N2 - BACKGROUND: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD.MATERIALS AND METHODS: Participants in The Danish Blood Donor Study (2010-2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests.RESULTS: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09-1.31), C*01:02, OR 1.19 (95% CI: 1.08-1.32), C*06:02, OR 1.14 (95% CI: 1.08-1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04-1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85-0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85-0.94).CONCLUSION: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.

AB - BACKGROUND: The human leukocyte antigen system (HLA) is divided into two classes involved in antigen presentation: class I presenting intracellular antigens and class II presenting extracellular antigens. While susceptibility to infections is correlated with the HLA system, data on associations between HLA genotypes and Malassezia-related skin diseases (MRSD) are lacking. Thus, the objective of this study was to investigate associations between HLA alleles and MRSD.MATERIALS AND METHODS: Participants in The Danish Blood Donor Study (2010-2018) provided questionnaire data on life style, anthropometric measures, and registry data on filled prescriptions. Genotyping was done using Illumina Infinium Global Screening Array, and HLA alleles were imputed using the HIBAG algorithm. Cases and controls were defined using filled prescriptions on topical ketoconazole 2% as a proxy of MRSD. Logistic regressions assessed associations between HLA alleles and MRSD adjusted for confounders and Bonferroni corrected for multiple tests.RESULTS: A total of 9455 participants were considered MRSD cases and 24,144 participants as controls. We identified four risk alleles B*57:01, OR 1.19 (95% CI: 1.09-1.31), C*01:02, OR 1.19 (95% CI: 1.08-1.32), C*06:02, OR 1.14 (95% CI: 1.08-1.22), and DRB1*01:01, OR 1.10 (95% CI: 1.04-1.17), and two protective alleles, DQB1*02:01, OR 0.89 (95% CI: 0.85-0.94), and DRB1*03:01, OR 0.89 (95% CI: 0.85-0.94).CONCLUSION: Five novel associations between HLA alleles and MRSD were identified in our cohort, and one previous association was confirmed. Future studies should assess the correlation between Malassezia antigens and antigen-binding properties of the associated HLA alleles.

KW - Blood donors

KW - Head and neck dermatitis

KW - Major histocompatibility complex

KW - Malassezia folliculitis

KW - Pityriasis versicolor

KW - Seborrheic dermatitis

KW - Dermatomycoses/blood

KW - Humans

KW - Middle Aged

KW - Genotype

KW - Male

KW - Skin Diseases, Genetic

KW - HLA Antigens/genetics

KW - Case-Control Studies

KW - Malassezia/genetics

KW - Blood Donors

KW - Alleles

KW - Denmark

KW - Adult

KW - Female

KW - Cohort Studies

UR - http://www.scopus.com/inward/record.url?scp=85142281004&partnerID=8YFLogxK

U2 - 10.1007/s00403-022-02454-9

DO - 10.1007/s00403-022-02454-9

M3 - Journal article

C2 - 36394635

VL - 315

SP - 895

EP - 902

JO - Archives of Dermatological Research

JF - Archives of Dermatological Research

SN - 0340-3696

IS - 4

ER -

Human leukocyte antigen system associations in Malassezia-related skin diseases

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