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Human leukocyte antigen (HLA)-G during pregnancy part II: associations between maternal and fetal HLA-G genotypes and soluble HLA-G

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  • Mette Dahl
  • Louise Klitkou
  • Ole B Christiansen
  • Snezana Djurisic
  • Zofia Maria Piosik
  • Peter Skovbo
  • Anna Margrethe Møller
  • Rudi Steffensen
  • Thomas Vauvert F Hviid
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Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue distribution expressed on the extra-villous trophoblast and seems to have immunomodulatory functions during pregnancy. Studies have linked HLA-G polymorphisms to pregnancy complications such as preeclampsia and recurrent miscarriage. Levels of soluble HLA-G (sHLA-G) in blood plasma from non-pregnant donors seem to be associated with these polymorphisms. In the current study, we have genotyped 246 mothers and their offspring for HLA-G polymorphisms in the 3'-untranslated region (3'UTR) and measured sHLA-G in maternal blood plasma samples from gestational week 20 and at term, as well as in fetal umbilical cord blood samples. This is the first large study simultaneously performing HLA-G genotyping of mother and offspring and measuring sHLA-G in both maternal and umbilical cord blood. The results showed that increasing numbers of 14bp ins (rs66554220) alleles in the mother-child genotype combinations were associated with higher maternal sHLA-G levels at term when restricting the analysis to 14bp ins/del heterozygous mothers (p=0.015). Furthermore, increasing numbers of 14InsG haplotypes (14bp ins/del and +3142C/G (rs1063320) polymorphism) in mother-child genotype combinations were associated with higher levels of sHLA-G at term in heterozygous 14DelC/14InsG mothers (p=0.005). In conclusion, the results indicate that there is an association between combined feto-maternal HLA-G genotypes and sHLA-G levels in maternal blood plasma.

Original languageEnglish
JournalHuman Immunology
Volume76
Issue number4
Pages (from-to)260-71
Number of pages12
ISSN0198-8859
DOIs
Publication statusPublished - Apr 2015

    Research areas

  • 3' Untranslated Regions, Abortion, Habitual, Alleles, DNA Mutational Analysis, Female, Fetal Blood, Genetic Predisposition to Disease, Genotype, Gestational Age, HLA-G Antigens, Histocompatibility, Humans, Polymorphism, Genetic, Pre-Eclampsia, Pregnancy

ID: 46176234