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Human leukocyte antigen (HLA)-G during pregnancy part I: correlations between maternal soluble HLA-G at midterm, at term, and umbilical cord blood soluble HLA-G at term

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  1. Expression and differential regulation of HLA-G isoforms in the retinal pigment epithelial cell line, ARPE-19

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  2. Human leukocyte antigen (HLA)-G during pregnancy part II: associations between maternal and fetal HLA-G genotypes and soluble HLA-G

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  3. CD4+ CD31+ recent thymic emigrants in CHD7 haploinsufficiency (CHARGE syndrome): a case

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  1. HLA-DRB1 polymorphism in recurrent pregnancy loss: New evidence for an association to HLA-DRB1*07

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  2. Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

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  3. Thyroid peroxidase antibodies and prospective live birth rate: A cohort study of women with recurrent pregnancy loss

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  4. Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum

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  5. Recurrence rates after abdominal and vaginal cerclages in women with cervical insufficiency: a validated cohort study

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  • Louise Klitkou
  • Mette Dahl
  • Thomas Vauvert F Hviid
  • Snezana Djurisic
  • Zofia Maria Piosik
  • Peter Skovbo
  • Anna Margrethe Møller
  • Rudi Steffensen
  • Ole B Christiansen
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Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue distribution expressed on trophoblast cells and has been proposed to have immunomodulatory functions during pregnancy. Soluble HLA-G1 (sHLA-G1) can be generated by the shedding of membrane-bound HLA-G molecules; however, three soluble isoforms also exist (HLA-G5 to -G6). During pregnancy, it is unknown whether there is a correlation between sHLA-G levels in maternal and fetal blood. In 246 pregnancies, we have measured the levels of sHLA-G1/-G5 in maternal blood plasma samples from gestational week 20 (GW20) and at term, as well as in umbilical cord blood samples. Soluble HLA-G levels declined by 38.4% in maternal blood from GW20 to term, and sHLA-G levels were significantly lower in maternal blood at term than in GW20 (P<0.001). At term, the sHLA-G levels were significantly higher in maternal blood than in umbilical blood (P<0.001). HLA-G levels in maternal blood in GW20 and at term, and in maternal blood at term and umbilical cord blood, were correlated (P<0.001 and P<0.01, respectively). This is the first large study simultaneously measuring sHLA-G in both maternal and umbilical cord blood. The finding that sHLA-G levels are significantly lower in fetal compared with maternal blood at term documents for the first time that sHLA-G is not freely transferred over the placental barrier. Soluble HLA-G levels in maternal and fetal blood were found to be correlated, which may be due to shared genetic factors of importance for production of sHLA-G in the mother and child, or it may support the theory that sHLA-G in the pregnant woman and the fetus is partly derived from a "shared organ", the placenta.

Original languageEnglish
JournalHuman Immunology
Volume76
Issue number4
Pages (from-to)254-9
Number of pages6
ISSN0198-8859
DOIs
Publication statusPublished - Apr 2015

    Research areas

  • Cohort Studies, Female, Fetal Blood, Follow-Up Studies, Gestational Age, HLA-G Antigens, Humans, Immunity, Maternally-Acquired, Placental Circulation, Pregnancy, Pregnancy Trimester, Second

ID: 46176199