Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats

Pauliina Luoto; Iina Laitinen; Sami Suilamo; Kjell Någren; Anne Roivainen

doi:10.1007/s11307-009-0293-1

Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats

Pauliina Luoto, Iina Laitinen, Sami Suilamo, Kjell Någren, Anne Roivainen

Department of Clinical Physiology and Nuclear Medicine

7 Citations (Scopus)

Abstract

Carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide ([11C]PK11195) is a peripheral benzodiazepine receptor (PBR) antagonist that is used as a positron emission tomography (PET) radiopharmaceutical for neuroinflammatory imaging. This study was designed to investigate the radiation dosimetry of [11C]PK11195.

Original language	English
Journal	Molecular Imaging and Biology
Volume	12
Issue number	4
Pages (from-to)	435-42
Number of pages	8
ISSN	1536-1632
DOIs	https://doi.org/10.1007/s11307-009-0293-1
Publication status	Published - 1 Aug 2010

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Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats. / Luoto, Pauliina; Laitinen, Iina; Suilamo, Sami et al.
In: Molecular Imaging and Biology, Vol. 12, No. 4, 01.08.2010, p. 435-42.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Laitinen, Iina

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AU - Någren, Kjell

AU - Roivainen, Anne

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Human dosimetry of carbon-11 labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide extrapolated from whole-body distribution kinetics and radiometabolism in rats

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