TY - JOUR
T1 - HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13
AU - Asad, Samina
AU - Nikamo, Pernilla
AU - Gyllenberg, Alexandra
AU - Bennet, Hedvig
AU - Hansson, Ola
AU - Wierup, Nils
AU - Carlsson, Annelie
AU - Forsander, Gun
AU - Ivarsson, Sten-Anders
AU - Larsson, Helena
AU - Lernmark, Åke
AU - Lindblad, Bengt
AU - Ludvigsson, Johnny
AU - Marcus, Claude
AU - Rønningen, Kjersti S
AU - Nerup, Jørn
AU - Pociot, Flemming
AU - Luthman, Holger
AU - Fex, Malin
AU - Kockum, Ingrid
AU - Diabetes Incidence in Sweden Study Group
PY - 2012
Y1 - 2012
N2 - We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD≤2.2) to the chromosome 5p13-q13 region. The aim of our study was to investigate the linked region in search for possible T1D susceptibility genes.
AB - We have previously performed a genome-wide linkage study in Scandinavian Type 1 diabetes (T1D) families. In the Swedish families, we detected suggestive linkage (LOD≤2.2) to the chromosome 5p13-q13 region. The aim of our study was to investigate the linked region in search for possible T1D susceptibility genes.
KW - Chromosome Mapping
KW - Chromosomes, Human, Pair 5
KW - Denmark
KW - Diabetes Mellitus, Type 1
KW - Family Health
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Genotype
KW - Humans
KW - Immunohistochemistry
KW - Islets of Langerhans
KW - Linkage Disequilibrium
KW - Lod Score
KW - Pancrelipase
KW - Polymorphism, Single Nucleotide
KW - Receptor, Serotonin, 5-HT1A
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Sweden
KW - Ubiquitin-Protein Ligases
U2 - 10.1371/journal.pone.0035439
DO - 10.1371/journal.pone.0035439
M3 - Journal article
C2 - 22563461
SN - 1932-6203
VL - 7
SP - e35439
JO - P L o S One
JF - P L o S One
IS - 5
ER -