Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ultraviolet radiation drives mutations in a subset of mucosal melanomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Meropenem to Children With Febrile Neutropenia Induces Monoresistant Pseudomonas aeruginosa

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Therapeutic drug monitoring of β-lactam antibiotics

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Oxacillinase-181 Carbapenemase-Producing Klebsiella pneumoniae in Neonatal Intensive Care Unit, Ghana, 2017-2019

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Escherichia coli is the leading cause of urinary tract infection, one of the most common bacterial infections in humans. Despite this, a genomic perspective is lacking regarding the phylogenetic distribution of isolates associated with different clinical syndromes. Here, we present a large-scale phylogenomic analysis of a spatiotemporally and clinically diverse set of 907 E. coli isolates, including 722 uropathogenic E. coli (UPEC) isolates. A genome-wide association approach identifies the (P-fimbriae-encoding) papGII locus as the key feature distinguishing invasive UPEC, defined as isolates associated with severe UTI, i.e., kidney infection (pyelonephritis) or urinary-source bacteremia, from non-invasive UPEC, defined as isolates associated with asymptomatic bacteriuria or bladder infection (cystitis). Within the E. coli population, distinct invasive UPEC lineages emerged through repeated horizontal acquisition of diverse papGII-containing pathogenicity islands. Our findings elucidate the molecular determinants of severe UTI and have implications for the early detection of this pathogen.

Original languageEnglish
JournalNature Communications
Volume11
Issue number1
Pages (from-to)5968
ISSN2041-1723
DOIs
Publication statusPublished - 24 Nov 2020

    Research areas

  • Adhesins, Escherichia coli/genetics, DNA, Bacterial/genetics, Escherichia coli Infections/microbiology, Fimbriae, Bacterial/genetics, Gene Transfer, Horizontal/genetics, Genome, Bacterial, Genome-Wide Association Study, Genomic Islands/genetics, Humans, Phylogeny, Urinary Tract/microbiology, Urinary Tract Infections/microbiology, Uropathogenic Escherichia coli/genetics, Virulence Factors/genetics

ID: 61827370