Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

Hreinn Stefansson; G Bragi Walters; Gardar Sveinbjornsson; Vinicius Tragante; Gudmundur Einarsson; Hannes Helgason; Asgeir Sigurðsson; Doruk Beyter; Audunn S Snaebjarnarson; Erna V Ivarsdottir; Gudmar Thorleifsson; Bjarni V Halldorsson; Gudmundur Norddahl; Unnur Styrkarsdottir; Arni Sturluson; Hilma Holm; Agnar Helgason; Kristjan Moore; Hannes P Eggertsson; Asmundur H Oddsson; Gudrun A Jonsdottir; Arni F Gunnarsson; Gyda Bjornsdottir; Rosa S Gisladottir; Thorgeir E Thorgeirsson; Astros Skuladottir; Daniel F Gudbjartsson; Patrick Sulem; Palmi Jonsson; Steinunn Thordardottir; Jon Snaedal; Helga Eyjolfsdottir; Byron Creese; Clive Ballard; Anne Corbett; Miguel Vasconcelos Da Silva; Dag Aarsland; Ole A Andreassen; Thomas Werge; Karina Banasik; Søren Brunak; Henrik Ullum; Ruth Frikke-Schmidt; Sisse R Ostrowski; Maria Didriksen; Erik Sørensen; Anja H Simonsen; Jørgen E Nielsen; Gunhild Waldemar; Ole B Pedersen; DemGen Study Group

doi:10.1056/NEJMc2314334

Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

Hreinn Stefansson, G Bragi Walters, Gardar Sveinbjornsson, Vinicius Tragante, Gudmundur Einarsson, Hannes Helgason, Asgeir Sigurðsson, Doruk Beyter, Audunn S Snaebjarnarson, Erna V Ivarsdottir, Gudmar Thorleifsson, Bjarni V Halldorsson, Gudmundur Norddahl, Unnur Styrkarsdottir, Arni Sturluson, Hilma Holm, Agnar Helgason, Kristjan Moore, Hannes P Eggertsson, Asmundur H OddssonGudrun A Jonsdottir, Arni F Gunnarsson, Gyda Bjornsdottir, Rosa S Gisladottir, Thorgeir E Thorgeirsson, Astros Skuladottir, Daniel F Gudbjartsson, Patrick Sulem, Palmi Jonsson, Steinunn Thordardottir, Jon Snaedal, Helga Eyjolfsdottir, Byron Creese, Clive Ballard, Anne Corbett, Miguel Vasconcelos Da Silva, Dag Aarsland, Ole A Andreassen, Thomas Werge, Karina Banasik, Søren Brunak, Henrik Ullum, Ruth Frikke-Schmidt, Sisse R Ostrowski, Maria Didriksen, Erik Sørensen, Anja H Simonsen, Jørgen E Nielsen, Gunhild Waldemar, Ole B Pedersen, DemGen Study Group

1 Citation (Scopus)

Original language	English
Journal	The New England journal of medicine
Volume	390
Issue number	23
Pages (from-to)	2217-2219
Number of pages	3
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMc2314334
Publication status	Published - 20 Jun 2024

Keywords

Humans
Alzheimer Disease/genetics
Receptors, Immunologic/genetics
Membrane Glycoproteins/genetics
Homozygote
Genetic Predisposition to Disease
Aged
Female
Male

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10.1056/NEJMc2314334

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Stefansson, H., Walters, G. B., Sveinbjornsson, G., Tragante, V., Einarsson, G., Helgason, H., Sigurðsson, A., Beyter, D., Snaebjarnarson, A. S., Ivarsdottir, E. V., Thorleifsson, G., Halldorsson, B. V., Norddahl, G., Styrkarsdottir, U., Sturluson, A., Holm, H., Helgason, A., Moore, K., Eggertsson, H. P., ... DemGen Study Group (2024). Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease. The New England journal of medicine, 390(23), 2217-2219. https://doi.org/10.1056/NEJMc2314334

Stefansson, H, Walters, GB, Sveinbjornsson, G, Tragante, V, Einarsson, G, Helgason, H, Sigurðsson, A, Beyter, D, Snaebjarnarson, AS, Ivarsdottir, EV, Thorleifsson, G, Halldorsson, BV, Norddahl, G, Styrkarsdottir, U, Sturluson, A, Holm, H, Helgason, A, Moore, K, Eggertsson, HP, Oddsson, AH, Jonsdottir, GA, Gunnarsson, AF, Bjornsdottir, G, Gisladottir, RS, Thorgeirsson, TE, Skuladottir, A, Gudbjartsson, DF, Sulem, P, Jonsson, P, Thordardottir, S, Snaedal, J, Eyjolfsdottir, H, Creese, B, Ballard, C, Corbett, A, Vasconcelos Da Silva, M, Aarsland, D, Andreassen, OA, Werge, T , Banasik, K , Brunak, S, Ullum, H, Frikke-Schmidt, R , Ostrowski, SR , Didriksen, M , Sørensen, E , Simonsen, AH , Nielsen, JE , Waldemar, G, Pedersen, OB & DemGen Study Group 2024, 'Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease', The New England journal of medicine, vol. 390, no. 23, pp. 2217-2219. https://doi.org/10.1056/NEJMc2314334

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title = "Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease",

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AU - Stefansson, Hreinn

AU - Walters, G Bragi

AU - Sveinbjornsson, Gardar

AU - Tragante, Vinicius

AU - Einarsson, Gudmundur

AU - Helgason, Hannes

AU - Sigurðsson, Asgeir

AU - Beyter, Doruk

AU - Snaebjarnarson, Audunn S

AU - Ivarsdottir, Erna V

AU - Thorleifsson, Gudmar

AU - Halldorsson, Bjarni V

AU - Norddahl, Gudmundur

AU - Styrkarsdottir, Unnur

AU - Sturluson, Arni

AU - Holm, Hilma

AU - Helgason, Agnar

AU - Moore, Kristjan

AU - Eggertsson, Hannes P

AU - Oddsson, Asmundur H

AU - Jonsdottir, Gudrun A

AU - Gunnarsson, Arni F

AU - Bjornsdottir, Gyda

AU - Gisladottir, Rosa S

AU - Thorgeirsson, Thorgeir E

AU - Skuladottir, Astros

AU - Gudbjartsson, Daniel F

AU - Sulem, Patrick

AU - Jonsson, Palmi

AU - Thordardottir, Steinunn

AU - Snaedal, Jon

AU - Eyjolfsdottir, Helga

AU - Creese, Byron

AU - Ballard, Clive

AU - Corbett, Anne

AU - Vasconcelos Da Silva, Miguel

AU - Aarsland, Dag

AU - Andreassen, Ole A

AU - Werge, Thomas

AU - Banasik, Karina

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Frikke-Schmidt, Ruth

AU - Ostrowski, Sisse R

AU - Didriksen, Maria

AU - Sørensen, Erik

AU - Simonsen, Anja H

AU - Nielsen, Jørgen E

AU - Waldemar, Gunhild

AU - Pedersen, Ole B

AU - DemGen Study Group

PY - 2024/6/20

Y1 - 2024/6/20

KW - Humans

KW - Alzheimer Disease/genetics

KW - Receptors, Immunologic/genetics

KW - Membrane Glycoproteins/genetics

KW - Homozygote

KW - Genetic Predisposition to Disease

KW - Aged

KW - Female

KW - Male

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DO - 10.1056/NEJMc2314334

M3 - Comment/debate

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SN - 0028-4793

VL - 390

SP - 2217

EP - 2219

JO - The New England journal of medicine

JF - The New England journal of medicine

IS - 23

ER -

Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease

Keywords

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