Hjerneskademarkøren S100B kan mindske brugen af computertomografi ved lette hovedtraumer--sekundaerpublikation

Jacob Bertram Springborg; Johan Undén; Tor Ingebrigtsen; Bertil Romner

Hjerneskademarkøren S100B kan mindske brugen af computertomografi ved lette hovedtraumer--sekundaerpublikation

Translated title of the contribution: Brain injury marker S100B can reduce the use of computer tomography in minor head injuries--secondary publication

Jacob Bertram Springborg, Johan Undén, Tor Ingebrigtsen, Bertil Romner

Department of Neurosurgery

14 Citations (Scopus)

Abstract

The risk of acute intracranial complications after minor head injury (MHI) is low. Despite this, computed tomography (CT) is generally recommended with clinical observation as a secondary option. Both options have disadvantages. Clinical studies have shown the potential advantages of using the biomarker S100B. The specificity of S100B is low, but a high sensitivity for brain damage results in a clinically useful, high negative predictive value (NPV). Integration of S100B into existing management routines can reduce the need for CT scans or admission by over 30%.

Translated title of the contribution	Brain injury marker S100B can reduce the use of computer tomography in minor head injuries--secondary publication
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	171
Issue number	12
Pages (from-to)	978-81
Number of pages	4
ISSN	0041-5782
Publication status	Published - 16 Mar 2009

Cite this

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title = "Hjerneskademark{\o}ren S100B kan mindske brugen af computertomografi ved lette hovedtraumer--sekundaerpublikation",

abstract = "The risk of acute intracranial complications after minor head injury (MHI) is low. Despite this, computed tomography (CT) is generally recommended with clinical observation as a secondary option. Both options have disadvantages. Clinical studies have shown the potential advantages of using the biomarker S100B. The specificity of S100B is low, but a high sensitivity for brain damage results in a clinically useful, high negative predictive value (NPV). Integration of S100B into existing management routines can reduce the need for CT scans or admission by over 30\%.",

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AU - Springborg, Jacob Bertram

AU - Undén, Johan

AU - Ingebrigtsen, Tor

AU - Romner, Bertil

PY - 2009/3/16

Y1 - 2009/3/16

N2 - The risk of acute intracranial complications after minor head injury (MHI) is low. Despite this, computed tomography (CT) is generally recommended with clinical observation as a secondary option. Both options have disadvantages. Clinical studies have shown the potential advantages of using the biomarker S100B. The specificity of S100B is low, but a high sensitivity for brain damage results in a clinically useful, high negative predictive value (NPV). Integration of S100B into existing management routines can reduce the need for CT scans or admission by over 30%.

AB - The risk of acute intracranial complications after minor head injury (MHI) is low. Despite this, computed tomography (CT) is generally recommended with clinical observation as a secondary option. Both options have disadvantages. Clinical studies have shown the potential advantages of using the biomarker S100B. The specificity of S100B is low, but a high sensitivity for brain damage results in a clinically useful, high negative predictive value (NPV). Integration of S100B into existing management routines can reduce the need for CT scans or admission by over 30%.

KW - Adult

KW - Biomarkers/blood

KW - Child

KW - Cost Savings

KW - Craniocerebral Trauma/blood

KW - Humans

KW - Nerve Growth Factors/blood

KW - Practice Guidelines as Topic

KW - Predictive Value of Tests

KW - S100 Calcium Binding Protein beta Subunit

KW - S100 Proteins/blood

KW - Sensitivity and Specificity

KW - Tomography, X-Ray Computed/economics

UR - https://www.scopus.com/pages/publications/63349099189

M3 - Tidsskriftartikel

C2 - 19301475

SN - 0041-5782

VL - 171

SP - 978

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JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 12

ER -

Hjerneskademarkøren S100B kan mindske brugen af computertomografi ved lette hovedtraumer--sekundaerpublikation

Abstract

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