Hjernens biologiske ur

Jan Fahrenkrug

Hjernens biologiske ur

Translated title of the contribution: The brain's biological clock

Jan Fahrenkrug

Department of Clinical Biochemistry

1 Citation (Scopus)

Abstract

Daily biological rhythms are controlled by a clock system, composed of a hierarchical multi-oscillator structure. Each cell in this system harbours a self-sustained autonomous molecular oscillator. Light adjusts the phase of the brain oscillator to the environmental light/dark cycle by intrinsically photosensitive retinal ganglion cells through their own photoreceptor, melanopsin, and by using the neuropeptide called pituitary adenylate cyclase-activating polypeptide as well as glutamate as neurotransmitters. The circadian synchronisation system is critical to health, and breakdown of the 24-hour temporal order could lead to pathological conditions.

Translated title of the contribution	The brain's biological clock
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	180
Issue number	36
ISSN	0041-5782
Publication status	Published - 3 Sept 2018

Cite this

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AB - Daily biological rhythms are controlled by a clock system, composed of a hierarchical multi-oscillator structure. Each cell in this system harbours a self-sustained autonomous molecular oscillator. Light adjusts the phase of the brain oscillator to the environmental light/dark cycle by intrinsically photosensitive retinal ganglion cells through their own photoreceptor, melanopsin, and by using the neuropeptide called pituitary adenylate cyclase-activating polypeptide as well as glutamate as neurotransmitters. The circadian synchronisation system is critical to health, and breakdown of the 24-hour temporal order could lead to pathological conditions.

UR - https://www.scopus.com/pages/publications/85055187693

M3 - Tidsskriftartikel

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VL - 180

JO - Ugeskrift for Laeger

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Hjernens biologiske ur

Abstract

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