Hiv kan og skal behandles samtidig med tuberkulose

Sarah von der Maase; Jan Gerstoft; Christian Wejse

Hiv kan og skal behandles samtidig med tuberkulose

Translated title of the contribution: Simultaneous treatment of HIV and tuberculosis is possible and necessary

Sarah von der Maase, Jan Gerstoft, Christian Wejse

Abstract

The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.

Translated title of the contribution	Simultaneous treatment of HIV and tuberculosis is possible and necessary
Original language	Danish
Article number	V03130163
Journal	Ugeskrift for Laeger
Volume	176
Issue number	6A
ISSN	0041-5782
Publication status	Published - 3 Feb 2014

Cite this

@article{e19074ae5ca542edb9e611fd3b1aa2a1,

title = "Hiv kan og skal behandles samtidig med tuberkulose",

abstract = "The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.",

keywords = "AIDS-Related Opportunistic Infections/complications, Anti-Retroviral Agents/adverse effects, CD4 Lymphocyte Count, Coinfection, Early Medical Intervention, HIV Infections/complications, Humans, Immune Reconstitution Inflammatory Syndrome/chemically induced, Tuberculosis/complications",

author = "\{von der Maase\}, Sarah and Jan Gerstoft and Christian Wejse",

year = "2014",

month = feb,

day = "3",

language = "Dansk",

volume = "176",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

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TY - JOUR

T1 - Hiv kan og skal behandles samtidig med tuberkulose

AU - von der Maase, Sarah

AU - Gerstoft, Jan

AU - Wejse, Christian

PY - 2014/2/3

Y1 - 2014/2/3

N2 - The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.

AB - The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.

KW - AIDS-Related Opportunistic Infections/complications

KW - Anti-Retroviral Agents/adverse effects

KW - CD4 Lymphocyte Count

KW - Coinfection

KW - Early Medical Intervention

KW - HIV Infections/complications

KW - Humans

KW - Immune Reconstitution Inflammatory Syndrome/chemically induced

KW - Tuberculosis/complications

UR - https://ugeskriftet.dk/videnskab/hiv-kan-og-skal-behandles-samtidig-med-tuberkulose

M3 - Review

C2 - 25347439

SN - 0041-5782

VL - 176

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 6A

M1 - V03130163

ER -

Hiv kan og skal behandles samtidig med tuberkulose

Abstract

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