History of key regulatory peptide systems and perspectives for future research

Duan Chen*, Jens F Rehfeld, Alan G Watts, Patrik Rorsman, Andrew L Gundlach

*Corresponding author for this work
2 Citations (Scopus)


Throughout the 20th Century, regulatory peptide discovery advanced from the identification of gut hormones to the extraction and characterization of hypothalamic hypophysiotropic factors, and to the isolation and cloning of multiple brain neuropeptides. These discoveries were followed by the discovery of G-protein-coupled and other membrane receptors for these peptides. Subsequently, the systems physiology associated with some of these multiple regulatory peptides and receptors has been comprehensively elucidated and has led to improved therapeutics and diagnostics and their approval by the US Food and Drug Administration. In light of this wealth of information and further potential, it is truly a time of renaissance for regulatory peptides. In this perspective, we review what we have learned from the pioneers in exemplified fields of gut peptides, such as cholecystokinin, enterochromaffin-like-cell peptides, and glucagon, from the trailblazing studies on the key stress hormone, corticotropin-releasing factor, as well as from more recently characterized relaxin-family peptides and receptors. The historical viewpoints are based on our understanding of these topics in light of the earliest phases of research and on subsequent studies and the evolution of knowledge, aiming to sharpen our vision of the current state-of-the-art and those studies that should be prioritized in the future.

Original languageEnglish
Article numbere13251
JournalJournal of Neuroendocrinology
Issue number11
Pages (from-to)e13251
Publication statusPublished - Nov 2023


  • Cholecystokinin
  • Corticotropin-Releasing Hormone
  • Glucagon
  • Neuropeptides
  • Relaxin
  • corticotropin-releasing factor
  • cholecystokinin
  • glucagon
  • relaxin-family peptides
  • enterochromaffin-like cells


Dive into the research topics of 'History of key regulatory peptide systems and perspectives for future research'. Together they form a unique fingerprint.

Cite this