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High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

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Harvard

Moberg, M, Apró, W, Cervenka, I, Ekblom, B, van Hall, G, Holmberg, H-C, Ruas, JL & Blomstrand, E 2021, 'High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles', Scientific Reports, vol. 11, no. 1, 6453. https://doi.org/10.1038/s41598-021-85733-1

APA

Moberg, M., Apró, W., Cervenka, I., Ekblom, B., van Hall, G., Holmberg, H-C., Ruas, J. L., & Blomstrand, E. (2021). High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles. Scientific Reports, 11(1), [6453]. https://doi.org/10.1038/s41598-021-85733-1

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MLA

Vancouver

Author

Moberg, Marcus ; Apró, William ; Cervenka, Igor ; Ekblom, Björn ; van Hall, Gerrit ; Holmberg, Hans-Christer ; Ruas, Jorge L ; Blomstrand, Eva. / High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

Bibtex

@article{1aab4cf3934a43998d74ec98f8ae3102,
title = "High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles",
abstract = "This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resistance exercise (ER-Arm), and one with upper body resistance exercise only (R-Arm). Biopsies were taken from the triceps prior to and immediately, 90- and 180-min following exercise. Immediately after resistance exercise, the elevation in S6K1 activity was smaller and the 4E-BP1:eIF4E interaction greater in ER-Arm, but this acute attenuation disappeared during recovery. The protein synthetic rate in triceps was greater following exercise than at rest, with no difference between trials. The level of PGC-1α1 mRNA increased to greater extent in ER-Arm than R-Arm after 90 min of recovery, as was PGC-1α4 mRNA after both 90 and 180 min. Levels of MuRF-1 mRNA was unchanged in R-Arm, but elevated during recovery in ER-Arm, whereas MAFbx mRNA levels increased slightly in both trials. RNA sequencing in a subgroup of subjects revealed 862 differently expressed genes with ER-Arm versus R-Arm during recovery. These findings suggest that leg cycling prior to arm resistance exercise causes systemic changes that potentiate induction of specific genes in the triceps, without compromising the anabolic response.",
author = "Marcus Moberg and William Apr{\'o} and Igor Cervenka and Bj{\"o}rn Ekblom and {van Hall}, Gerrit and Hans-Christer Holmberg and Ruas, {Jorge L} and Eva Blomstrand",
year = "2021",
month = mar,
day = "19",
doi = "10.1038/s41598-021-85733-1",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

AU - Moberg, Marcus

AU - Apró, William

AU - Cervenka, Igor

AU - Ekblom, Björn

AU - van Hall, Gerrit

AU - Holmberg, Hans-Christer

AU - Ruas, Jorge L

AU - Blomstrand, Eva

PY - 2021/3/19

Y1 - 2021/3/19

N2 - This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resistance exercise (ER-Arm), and one with upper body resistance exercise only (R-Arm). Biopsies were taken from the triceps prior to and immediately, 90- and 180-min following exercise. Immediately after resistance exercise, the elevation in S6K1 activity was smaller and the 4E-BP1:eIF4E interaction greater in ER-Arm, but this acute attenuation disappeared during recovery. The protein synthetic rate in triceps was greater following exercise than at rest, with no difference between trials. The level of PGC-1α1 mRNA increased to greater extent in ER-Arm than R-Arm after 90 min of recovery, as was PGC-1α4 mRNA after both 90 and 180 min. Levels of MuRF-1 mRNA was unchanged in R-Arm, but elevated during recovery in ER-Arm, whereas MAFbx mRNA levels increased slightly in both trials. RNA sequencing in a subgroup of subjects revealed 862 differently expressed genes with ER-Arm versus R-Arm during recovery. These findings suggest that leg cycling prior to arm resistance exercise causes systemic changes that potentiate induction of specific genes in the triceps, without compromising the anabolic response.

AB - This study examined acute molecular responses to concurrent exercise involving different muscles. Eight men participated in a randomized crossover-trial with two sessions, one where they performed interval cycling followed by upper body resistance exercise (ER-Arm), and one with upper body resistance exercise only (R-Arm). Biopsies were taken from the triceps prior to and immediately, 90- and 180-min following exercise. Immediately after resistance exercise, the elevation in S6K1 activity was smaller and the 4E-BP1:eIF4E interaction greater in ER-Arm, but this acute attenuation disappeared during recovery. The protein synthetic rate in triceps was greater following exercise than at rest, with no difference between trials. The level of PGC-1α1 mRNA increased to greater extent in ER-Arm than R-Arm after 90 min of recovery, as was PGC-1α4 mRNA after both 90 and 180 min. Levels of MuRF-1 mRNA was unchanged in R-Arm, but elevated during recovery in ER-Arm, whereas MAFbx mRNA levels increased slightly in both trials. RNA sequencing in a subgroup of subjects revealed 862 differently expressed genes with ER-Arm versus R-Arm during recovery. These findings suggest that leg cycling prior to arm resistance exercise causes systemic changes that potentiate induction of specific genes in the triceps, without compromising the anabolic response.

UR - http://www.scopus.com/inward/record.url?scp=85102873780&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-85733-1

DO - 10.1038/s41598-021-85733-1

M3 - Journal article

C2 - 33742064

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6453

ER -

ID: 64827504