Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT

Niels Jacobsen*, Tina Frisch, Niels Keiding, Carsten Heilmann, Henrik Sengeløv, Hans O Madsen, Ebbe Dickmeiss, Lars P Ryder

*Corresponding author for this work

Abstract

The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).

Original languageEnglish
JournalEJHaem
Volume3
Issue number3
Pages (from-to)975-979
Number of pages5
ISSN2688-6146
DOIs
Publication statusPublished - Aug 2022

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