Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Higher chlorzoxazone clearance in obese children compared with nonobese peers

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Low-dose aspirin use and risk of head and neck cancer-A Danish nationwide case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Drug-drug interaction between warfarin and statins: A Danish cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Obesity-induced CYP2E1 activity in children

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Body weight and metabolic risk factors in patients with type 2 diabetes on a self-selected high-protein low-carbohydrate diet

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Increments in DNA-thioguanine level during thiopurine enhanced maintenance therapy of acute lymphoblastic leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Using machine learning for predicting intensive care unit resource use during the COVID-19 pandemic in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Challenges in conducting paediatric trials with off-patent drugs

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Variable oxygen administration in surgical and medical wards evaluated by 30-day mortality - an observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIMS: To test the in vivo activity of Cytochrome P450 (CYP) 2E1 in obese children vs. nonobese children, aged 11-18 years. Secondly, whether the activity of CYP2E1 in these patients is associated with NALFD, diabetes or hyperlipidaemia.

METHODS: Seventy children were divided into groups by body mass index (BMI) standard deviation score (SDS). All children received 250 mg oral chlorzoxazone (CLZ) as probe for CYP2E1 activity. Thirteen blood samples and 20-h urine samples were collected per participant.

RESULTS: Obese children had an increased oral clearance and distribution of CLZ, indicating increased CYP2E1 activity, similar to obese adults. The mean AUC0-∞ value of CLZ was decreased by 46% in obese children compared to nonobese children. The F was was increased twofold in obese children compared to nonobese children, P < 0.0001. Diabetic biomarkers were significantly increased in obese children, while fasting blood glucose and Hba1c levels were nonsignificant between groups. Liver fat content was not associated with CLZ Cl.

CONCLUSION: Oral clearance of CLZ was increased two-fold in obese children vs. nonobese children aged 11-18 years. This indicates an increased CYP2E1 activity of clinical importance, and dose adjustment should be considered for CLZ.

Original languageEnglish
JournalBritish Journal of Clinical Pharmacology
Volume84
Issue number8
Pages (from-to)1738-1747
Number of pages10
ISSN0306-5251
DOIs
Publication statusPublished - Aug 2018

ID: 55664155