Abstract
The use of copper-based positron emission tomography (PET) tracers in cancer studies is increasing. However, as copper has previously been found in high concentrations in human tumor tissue in vivo, instability of PET tracers could result in tumor accumulation of non-tracer-bound radioactive copper that may influence PET measurements. Here we determine the degree of (64)Cu uptake in five commonly used human cancer xenograft models in mice. Additionally, we compare copper accumulation in tumor tissue to gene expression of human copper transporter 1 (CTR1).
| Original language | English |
|---|---|
| Journal | Nuclear Medicine and Biology |
| Volume | 40 |
| Issue number | 3 |
| Pages (from-to) | 345-50 |
| Number of pages | 6 |
| ISSN | 0969-8051 |
| DOIs | |
| Publication status | Published - Apr 2013 |
Keywords
- Animals
- Biological Transport
- Cation Transport Proteins
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Copper Radioisotopes
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Molecular Imaging
- Neoplasms
- Organ Specificity
- Positron-Emission Tomography
- Radioactive Tracers
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