High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis

Anne Mette Vestskov Larsen, Eva Birgitte Leinøe, Pär I Johansson, Henrik Birgens, Sisse R Ostrowski

24 Citations (Scopus)

Abstract

The risk of hemorrhage is influenced by multiple factors in acute myeloid leukemia (AML). We investigated whether hemorrhage in AML patients was associated with endothelial perturbation, potentially caused by thrombocytopenia, platelet dysfunction and leukocytosis. Biomarkers of endothelial perturbation, coagulation and platelet activation were analyzed in 49 AML patients, along with previously collected data on bleeding status and platelet activation markers. High levels of syndecan-1, a marker of endothelial glycocalyx degradation, were associated with bleeding, impaired platelet function, higher age, endothelial cell activation and damage, and leukocytosis. We suggest that platelet dysfunction and leukocytosis in AML causes endothelial perturbation.
Original languageEnglish
JournalAcute Myeloid Leukemia Research Today
Volume37
Issue number7
Pages (from-to)777-83
Number of pages7
ISSN1833-055X
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Aged
  • Biological Markers
  • Blood Coagulation
  • Endothelium, Vascular
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Flow Cytometry
  • Follow-Up Studies
  • Hemorrhage
  • Humans
  • Leukemia, Myeloid, Acute
  • Leukocytosis
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Risk Factors
  • Syndecan-1
  • Thrombocytopenia

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