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High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

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@article{0f6ba766ba684751b207ceed405c05c2,
title = "High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI",
abstract = "High-resolution fMRI enables noninvasive mapping of the hemodynamic responses from individual penetrating vessels in animal brains. Here, a 2D multi-echo single-vessel fMRI (MESV-fMRI) method has been developed to map the fMRI signal from arterioles and venules with a 100 ms sampling rate at multiple echo times (TE, 3–30 ms) and short acquisition windows (<1 ms). The T 2*-weighted signal shows the increased extravascular effect on venule voxels as a function of TE. In contrast, the arteriole voxels show an increased fMRI signal with earlier onset than venules voxels at the short TE (3 ms) with increased blood inflow and volume effects. MESV-fMRI enables vessel-specific T2* mapping and presents T2*-based fMRI time courses with higher contrast-to-noise ratios (CNRs) than the T2*-weighted fMRI signal at a given TE. The vessel-specific T2* mapping also allows semi-quantitative estimation of the oxygen saturation levels (Y) and their changes (ΔY) at a given blood volume fraction upon neuronal activation. The MESV-fMRI method enables vessel-specific T2* measurements with high spatiotemporal resolution for better modeling of the fMRI signal based on the hemodynamic parameters. ",
keywords = "Hemodynamic signal, multi-echo fMRI, neurovascular coupling, single-vessel fMRI, vascular dynamics",
author = "Yi He and Maosen Wang and Xin Yu",
year = "2020",
month = oct,
day = "1",
doi = "10.1177/0271678X19886240",
language = "English",
volume = "40",
pages = "2098--2114",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

AU - He, Yi

AU - Wang, Maosen

AU - Yu, Xin

PY - 2020/10/1

Y1 - 2020/10/1

N2 - High-resolution fMRI enables noninvasive mapping of the hemodynamic responses from individual penetrating vessels in animal brains. Here, a 2D multi-echo single-vessel fMRI (MESV-fMRI) method has been developed to map the fMRI signal from arterioles and venules with a 100 ms sampling rate at multiple echo times (TE, 3–30 ms) and short acquisition windows (<1 ms). The T 2*-weighted signal shows the increased extravascular effect on venule voxels as a function of TE. In contrast, the arteriole voxels show an increased fMRI signal with earlier onset than venules voxels at the short TE (3 ms) with increased blood inflow and volume effects. MESV-fMRI enables vessel-specific T2* mapping and presents T2*-based fMRI time courses with higher contrast-to-noise ratios (CNRs) than the T2*-weighted fMRI signal at a given TE. The vessel-specific T2* mapping also allows semi-quantitative estimation of the oxygen saturation levels (Y) and their changes (ΔY) at a given blood volume fraction upon neuronal activation. The MESV-fMRI method enables vessel-specific T2* measurements with high spatiotemporal resolution for better modeling of the fMRI signal based on the hemodynamic parameters.

AB - High-resolution fMRI enables noninvasive mapping of the hemodynamic responses from individual penetrating vessels in animal brains. Here, a 2D multi-echo single-vessel fMRI (MESV-fMRI) method has been developed to map the fMRI signal from arterioles and venules with a 100 ms sampling rate at multiple echo times (TE, 3–30 ms) and short acquisition windows (<1 ms). The T 2*-weighted signal shows the increased extravascular effect on venule voxels as a function of TE. In contrast, the arteriole voxels show an increased fMRI signal with earlier onset than venules voxels at the short TE (3 ms) with increased blood inflow and volume effects. MESV-fMRI enables vessel-specific T2* mapping and presents T2*-based fMRI time courses with higher contrast-to-noise ratios (CNRs) than the T2*-weighted fMRI signal at a given TE. The vessel-specific T2* mapping also allows semi-quantitative estimation of the oxygen saturation levels (Y) and their changes (ΔY) at a given blood volume fraction upon neuronal activation. The MESV-fMRI method enables vessel-specific T2* measurements with high spatiotemporal resolution for better modeling of the fMRI signal based on the hemodynamic parameters.

KW - Hemodynamic signal

KW - multi-echo fMRI

KW - neurovascular coupling

KW - single-vessel fMRI

KW - vascular dynamics

UR - http://www.scopus.com/inward/record.url?scp=85074997381&partnerID=8YFLogxK

U2 - 10.1177/0271678X19886240

DO - 10.1177/0271678X19886240

M3 - Journal article

C2 - 31696765

VL - 40

SP - 2098

EP - 2114

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 10

ER -

ID: 58330899