High Resolution Analysis of DMPK Hypermethylation and Repeat Interruptions in Myotonic Dystrophy Type 1

Keyphrases

• Myotonic Dystrophy 100%
• Methylation Status 100%
• Hypermethylation 100%
• Multiresolution Analysis 100%
• Repeat Interruptions 100%
• Repeat Length 75%
• CTG Repeat 75%
• Symptom Onset 25%
• Symptom Severity 25%
• Disease Severity 25%
• Large Cohort 25%
• Age of Onset 25%
• Neuromuscular Disease 25%
• Multisystemic 25%
• Germ Cells 25%
• Somatic Cells 25%
• 3′-untranslated Region (3′-UTR) 25%
• Epigenetic Biomarkers 25%
• Aberrant Methylation 25%
• Allele-specific Analysis 25%
• Oxford Nanopore Sequencing 25%
• Toxic Gain of Function 25%
• Expanded Repeats 25%
• Repeat-primed PCR 25%

Biochemistry, Genetics and Molecular Biology

• Methylation 100%
• Allele 50%
• Genetics 25%
• Polymerase Chain Reaction 25%
• Germline 25%
• Germ Cell 25%
• RNA 25%
• Somatic Cell 25%
• 3' Untranslated Region 25%
• DNA Flanking Region 25%

Neuroscience

• Methylation 100%
• Myotonic Dystrophy 100%
• Neuromuscular Disorder 25%
• 3' Untranslated Region 25%
• Germ Cell 25%
• DNA Flanking Region 25%
• Somatic Cell 25%
• Nanopore Sequencing 25%