High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation

Morten S Olesen, Lei Yuan, Bo Liang, Anders G Holst, Nikolaj Børty Nielsen, Jonas B Nielsen, Paula L Hedley, Michael Christiansen, Søren Peter Olesen, Stig Haunsø, Nicole Schmitt, Thomas Jespersen, Jesper H Svendsen

    114 Citations (Scopus)

    Abstract

    Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na(V)1.5, plays a pivotal role in setting the conduction velocity and the initial depolarization of the cardiac myocytes. We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A.
    Original languageEnglish
    JournalCirculation: Cardiovascular Genetics
    Volume5
    Issue number4
    Pages (from-to)450-9
    Number of pages10
    ISSN1942-325X
    DOIs
    Publication statusPublished - 2012

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