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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

High Parenteral Support Volume Is Associated With Reduced Quality of Life Determined by the Short-Bowel Syndrome Quality of Life Scale TM in Nonmalignant Intestinal Failure Patients.

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials

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  2. Repeated Metabolic Balance Studies in Patients With Short Bowel Syndrome

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  3. Impact of Teduglutide on Quality of Life Among Patients With Short Bowel Syndrome and Intestinal Failure

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  1. Effect and efficacy of lifestyle interventions as secondary prevention

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  2. Musculoskeletal pain reported by mobile patients with chronic kidney disease

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  3. Colon polyps in patients with short bowel syndrome before and after teduglutide: Post hoc analysis of the STEPS study series

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  4. Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials

    Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: Aim was to investigate the association between quality of life (QoL), bowel anatomy, and the need for home parenteral support (HPS) volume in patients with nonmalignant short-bowel syndrome (SBS) and intestinal failure (IF).

METHODS: The SBS-QoL scale was used in a cross-sectional study of 95 nonmalignant SBS-IF patients. Sum QoL scores (0: best, 170: worst) were calculated. Patients were defined as having a small bowel (≤200 cm), and patients with jejunostomy or ileostomy were subclassified based on functional small-bowel length (cm) into 4 anatomy subgroups: 1a-1d (0-49, 50-99, 100-149, 150-200 cm, respectively). Multiple linear regression analyses explored associations between QoL, patient groups, and HPS volume, adjusting for age, sex, body mass index, and education.

RESULTS: Complete data were obtained from 60 patients. HPS volume was associated with a worse SBS-QoL score (L/d, β = 7.91; SE = 3.90; P = .048), but male sex associated with improvement (β = -26.28; SE = 11.06; P = .021). No differences in sum QoL were seen between the benign SBS-IF subgroups 1a-d (P = .210). Multivariate regression analyses showed that patients with a small-bowel stoma, a small-bowel length <50 cm was associated with a significantly worse/higher SBS-QoL score compared with a length >50 cm.

CONCLUSION: In patients with benign SBS-IF, high HPS volume was associated with poor QoL. Also, jejunostomy or ileostomy with small-bowel length <50 cm was associated with impaired QoL. These findings support rehabilitation strategies that reduce fecal losses and decrease HPS needs.

Original languageEnglish
JournalJournal of Parenteral and Enteral Nutrition
ISSN0148-6071
DOIs
Publication statusE-pub ahead of print - 2 Jul 2020

Bibliographical note

© 2020 American Society for Parenteral and Enteral Nutrition.

    Research areas

  • adult parenteral nutrition, gastroenterology, home nutrition support, life cycle, short-bowel syndrome

ID: 60231984