High NT-proBNP is a strong predictor of outcome in elderly heart failure patients

Sven Andersson, Marie-Louise Edvinsson, Jonas Björk, Lars Edvinsson

20 Citations (Scopus)

Abstract

All patients older than 65 years (184 men; mean age, 78+/-0.8 years/181 women; mean age, 82+/-0.6 years) seeking medical attention at the Lund University Hospital Emergency Clinic during a 2-year period who had an N-terminal prohormone brain natriuretic peptide (NT-proBNP) value >2000 pg/mL were followed up for survival. Mortality in the entire population was 21% after 3 months, 35% after 1 year, and 40% after 2 years. Multivariate analysis indicated that the NT-proBNP level and the New York Heart Association (NYHA) functional class were stronger predictors of mortality than were echocardiographic estimation of left ventricular ejection fraction or chest radiography. Patients who survived the first year were younger, had higher systolic blood pressure, had lower plasma creatinine, had lower inflammatory activity, and were treated with lower doses of furosemide. The results indicate that in this population, NT-proBNP level together with assessment of NYHA class gives the best prognostic information of 1-year mortality.

Original languageEnglish
JournalThe American journal of geriatric cardiology
Volume17
Issue number1
Pages (from-to)13-20
Number of pages8
ISSN1076-7460
Publication statusPublished - 5 Jan 2008
Externally publishedYes

Keywords

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Female
  • Furosemide
  • Health Status
  • Health Status Indicators
  • Heart Failure
  • Humans
  • Male
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Prognosis
  • Prospective Studies
  • Sickness Impact Profile
  • Treatment Outcome

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