High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress

Anna C Molander; Adam Mar; Agnes Norbury; Sarah Steventon; Margarita Moreno; Daniele Caprioli; David E H Theobald; David Belin; Barry J Everitt; Trevor W Robbins; Jeffrey W Dalley

doi:10.1007/s00213-011-2167-x

High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress

Anna C Molander
, Adam Mar
, Agnes Norbury
, Sarah Steventon
, Margarita Moreno
, Daniele Caprioli
, David E H Theobald
, David Belin
, Barry J Everitt
, Trevor W Robbins
, Jeffrey W Dalley

86 Citations (Scopus)

Abstract

RATIONALE: Impulsivity is a vulnerability marker for drug addiction in which other behavioural traits such as anxiety and novelty seeking ('sensation seeking') are also widely present. However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood.

OBJECTIVE: The objective of this paper was to investigate the contribution of novelty seeking and anxiety traits to the expression of behavioural impulsivity in rats.

METHODS: Rats were screened on the five-choice serial reaction time task (5-CSRTT) for spontaneously high impulsivity (SHI) and low impulsivity (SLI) and subsequently tested for novelty reactivity and preference, assessed by open-field locomotor activity (OF), novelty place preference (NPP), and novel object recognition (OR). Anxiety was assessed on the elevated plus maze (EPM) both prior to and following the administration of the anxiolytic drug diazepam, and by blood corticosterone levels following forced novelty exposure. Finally, the effects of diazepam on impulsivity and visual attention were assessed in SHI and SLI rats.

RESULTS: SHI rats were significantly faster to enter an open arm on the EPM and exhibited preference for novelty in the OR and NPP tests, unlike SLI rats. However, there was no dimensional relationship between impulsivity and either novelty-seeking behaviour, anxiety levels, OF activity or novelty-induced changes in blood corticosterone levels. By contrast, diazepam (0.3-3 mg/kg), whilst not significantly increasing or decreasing impulsivity in SHI and SLI rats, did reduce the contrast in impulsivity between these two groups of animals.

CONCLUSIONS: This investigation indicates that behavioural impulsivity in rats on the 5-CSRTT, which predicts vulnerability for cocaine addiction, is distinct from anxiety, novelty reactivity and novelty-induced stress responses, and thus has relevance for the aetiology of drug addiction.

Original language	English
Journal	Psychopharmacology
Volume	215
Issue number	4
Pages (from-to)	721-31
Number of pages	11
ISSN	0033-3158
DOIs	https://doi.org/10.1007/s00213-011-2167-x
Publication status	Published - Jun 2011

Keywords

Animals
Anti-Anxiety Agents
Anxiety
Cocaine-Related Disorders
Conditioning, Operant
Corticosterone
Diazepam
Exploratory Behavior
Impulsive Behavior
Male
Maze Learning
Motor Activity
Predictive Value of Tests
Rats
Rats, Inbred Strains
Stress, Psychological

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10.1007/s00213-011-2167-x

Cite this

Molander, A. C., Mar, A., Norbury, A., Steventon, S., Moreno, M., Caprioli, D., Theobald, D. E. H., Belin, D., Everitt, B. J., Robbins, T. W., & Dalley, J. W. (2011). High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology, 215(4), 721-31. https://doi.org/10.1007/s00213-011-2167-x

Molander, AC, Mar, A, Norbury, A, Steventon, S, Moreno, M, Caprioli, D, Theobald, DEH, Belin, D, Everitt, BJ, Robbins, TW & Dalley, JW 2011, 'High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress', Psychopharmacology, vol. 215, no. 4, pp. 721-31. https://doi.org/10.1007/s00213-011-2167-x

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title = "High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress",

abstract = "RATIONALE: Impulsivity is a vulnerability marker for drug addiction in which other behavioural traits such as anxiety and novelty seeking ('sensation seeking') are also widely present. However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood.OBJECTIVE: The objective of this paper was to investigate the contribution of novelty seeking and anxiety traits to the expression of behavioural impulsivity in rats.METHODS: Rats were screened on the five-choice serial reaction time task (5-CSRTT) for spontaneously high impulsivity (SHI) and low impulsivity (SLI) and subsequently tested for novelty reactivity and preference, assessed by open-field locomotor activity (OF), novelty place preference (NPP), and novel object recognition (OR). Anxiety was assessed on the elevated plus maze (EPM) both prior to and following the administration of the anxiolytic drug diazepam, and by blood corticosterone levels following forced novelty exposure. Finally, the effects of diazepam on impulsivity and visual attention were assessed in SHI and SLI rats.RESULTS: SHI rats were significantly faster to enter an open arm on the EPM and exhibited preference for novelty in the OR and NPP tests, unlike SLI rats. However, there was no dimensional relationship between impulsivity and either novelty-seeking behaviour, anxiety levels, OF activity or novelty-induced changes in blood corticosterone levels. By contrast, diazepam (0.3-3 mg/kg), whilst not significantly increasing or decreasing impulsivity in SHI and SLI rats, did reduce the contrast in impulsivity between these two groups of animals.CONCLUSIONS: This investigation indicates that behavioural impulsivity in rats on the 5-CSRTT, which predicts vulnerability for cocaine addiction, is distinct from anxiety, novelty reactivity and novelty-induced stress responses, and thus has relevance for the aetiology of drug addiction.",

keywords = "Animals, Anti-Anxiety Agents, Anxiety, Cocaine-Related Disorders, Conditioning, Operant, Corticosterone, Diazepam, Exploratory Behavior, Impulsive Behavior, Male, Maze Learning, Motor Activity, Predictive Value of Tests, Rats, Rats, Inbred Strains, Stress, Psychological",

author = "Molander, \{Anna C\} and Adam Mar and Agnes Norbury and Sarah Steventon and Margarita Moreno and Daniele Caprioli and Theobald, \{David E H\} and David Belin and Everitt, \{Barry J\} and Robbins, \{Trevor W\} and Dalley, \{Jeffrey W\}",

year = "2011",

month = jun,

doi = "10.1007/s00213-011-2167-x",

language = "English",

volume = "215",

pages = "721--31",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "4",

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TY - JOUR

T1 - High impulsivity predicting vulnerability to cocaine addiction in rats

T2 - some relationship with novelty preference but not novelty reactivity, anxiety or stress

AU - Molander, Anna C

AU - Mar, Adam

AU - Norbury, Agnes

AU - Steventon, Sarah

AU - Moreno, Margarita

AU - Caprioli, Daniele

AU - Theobald, David E H

AU - Belin, David

AU - Everitt, Barry J

AU - Robbins, Trevor W

AU - Dalley, Jeffrey W

PY - 2011/6

Y1 - 2011/6

N2 - RATIONALE: Impulsivity is a vulnerability marker for drug addiction in which other behavioural traits such as anxiety and novelty seeking ('sensation seeking') are also widely present. However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood.OBJECTIVE: The objective of this paper was to investigate the contribution of novelty seeking and anxiety traits to the expression of behavioural impulsivity in rats.METHODS: Rats were screened on the five-choice serial reaction time task (5-CSRTT) for spontaneously high impulsivity (SHI) and low impulsivity (SLI) and subsequently tested for novelty reactivity and preference, assessed by open-field locomotor activity (OF), novelty place preference (NPP), and novel object recognition (OR). Anxiety was assessed on the elevated plus maze (EPM) both prior to and following the administration of the anxiolytic drug diazepam, and by blood corticosterone levels following forced novelty exposure. Finally, the effects of diazepam on impulsivity and visual attention were assessed in SHI and SLI rats.RESULTS: SHI rats were significantly faster to enter an open arm on the EPM and exhibited preference for novelty in the OR and NPP tests, unlike SLI rats. However, there was no dimensional relationship between impulsivity and either novelty-seeking behaviour, anxiety levels, OF activity or novelty-induced changes in blood corticosterone levels. By contrast, diazepam (0.3-3 mg/kg), whilst not significantly increasing or decreasing impulsivity in SHI and SLI rats, did reduce the contrast in impulsivity between these two groups of animals.CONCLUSIONS: This investigation indicates that behavioural impulsivity in rats on the 5-CSRTT, which predicts vulnerability for cocaine addiction, is distinct from anxiety, novelty reactivity and novelty-induced stress responses, and thus has relevance for the aetiology of drug addiction.

AB - RATIONALE: Impulsivity is a vulnerability marker for drug addiction in which other behavioural traits such as anxiety and novelty seeking ('sensation seeking') are also widely present. However, inter-relationships between impulsivity, novelty seeking and anxiety traits are poorly understood.OBJECTIVE: The objective of this paper was to investigate the contribution of novelty seeking and anxiety traits to the expression of behavioural impulsivity in rats.METHODS: Rats were screened on the five-choice serial reaction time task (5-CSRTT) for spontaneously high impulsivity (SHI) and low impulsivity (SLI) and subsequently tested for novelty reactivity and preference, assessed by open-field locomotor activity (OF), novelty place preference (NPP), and novel object recognition (OR). Anxiety was assessed on the elevated plus maze (EPM) both prior to and following the administration of the anxiolytic drug diazepam, and by blood corticosterone levels following forced novelty exposure. Finally, the effects of diazepam on impulsivity and visual attention were assessed in SHI and SLI rats.RESULTS: SHI rats were significantly faster to enter an open arm on the EPM and exhibited preference for novelty in the OR and NPP tests, unlike SLI rats. However, there was no dimensional relationship between impulsivity and either novelty-seeking behaviour, anxiety levels, OF activity or novelty-induced changes in blood corticosterone levels. By contrast, diazepam (0.3-3 mg/kg), whilst not significantly increasing or decreasing impulsivity in SHI and SLI rats, did reduce the contrast in impulsivity between these two groups of animals.CONCLUSIONS: This investigation indicates that behavioural impulsivity in rats on the 5-CSRTT, which predicts vulnerability for cocaine addiction, is distinct from anxiety, novelty reactivity and novelty-induced stress responses, and thus has relevance for the aetiology of drug addiction.

KW - Animals

KW - Anti-Anxiety Agents

KW - Anxiety

KW - Cocaine-Related Disorders

KW - Conditioning, Operant

KW - Corticosterone

KW - Diazepam

KW - Exploratory Behavior

KW - Impulsive Behavior

KW - Male

KW - Maze Learning

KW - Motor Activity

KW - Predictive Value of Tests

KW - Rats

KW - Rats, Inbred Strains

KW - Stress, Psychological

U2 - 10.1007/s00213-011-2167-x

DO - 10.1007/s00213-011-2167-x

M3 - Journal article

C2 - 21274702

SN - 0033-3158

VL - 215

SP - 721

EP - 731

JO - Psychopharmacology

JF - Psychopharmacology

IS - 4

ER -

High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress

Abstract

Keywords

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