High expression of MHC I in the tibialis anterior muscle of a paraplegic patient

A Hartkopp; J L Andersen; S D Harridge; C Crone; T Gruschy-Knudsen; M Kjaer; M Masao; A Ratkevicius; B Quistorff; S Zhou; F Biering-Sørensen

doi:10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c

High expression of MHC I in the tibialis anterior muscle of a paraplegic patient

A Hartkopp, J L Andersen, S D Harridge, C Crone, T Gruschy-Knudsen, M Kjaer, M Masao, A Ratkevicius, B Quistorff, S Zhou, F Biering-Sørensen

Department of Brain and Spinal Cord Injury

Abstract

A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy.

Original language	English
Journal	Muscle & Nerve
Volume	22
Issue number	12
Pages (from-to)	1731-7
Number of pages	7
ISSN	0148-639X
DOIs	https://doi.org/10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c
Publication status	Published - Dec 1999

Keywords

Electromyography
Humans
Immunohistochemistry
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle Contraction/physiology
Muscle, Skeletal/metabolism
Myosin Heavy Chains/biosynthesis
Paraplegia/metabolism
Protein Isoforms/biosynthesis
Spinal Cord Injuries/metabolism
Tibia

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10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c

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title = "High expression of MHC I in the tibialis anterior muscle of a paraplegic patient",

abstract = "A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy.",

keywords = "Electromyography, Humans, Immunohistochemistry, Magnetic Resonance Spectroscopy, Male, Middle Aged, Muscle Contraction/physiology, Muscle, Skeletal/metabolism, Myosin Heavy Chains/biosynthesis, Paraplegia/metabolism, Protein Isoforms/biosynthesis, Spinal Cord Injuries/metabolism, Tibia",

author = "A Hartkopp and Andersen, {J L} and Harridge, {S D} and C Crone and T Gruschy-Knudsen and M Kjaer and M Masao and A Ratkevicius and B Quistorff and S Zhou and F Biering-S{\o}rensen",

year = "1999",

month = dec,

doi = "10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c",

language = "English",

volume = "22",

pages = "1731--7",

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TY - JOUR

T1 - High expression of MHC I in the tibialis anterior muscle of a paraplegic patient

AU - Hartkopp, A

AU - Andersen, J L

AU - Harridge, S D

AU - Crone, C

AU - Gruschy-Knudsen, T

AU - Kjaer, M

AU - Masao, M

AU - Ratkevicius, A

AU - Quistorff, B

AU - Zhou, S

AU - Biering-Sørensen, F

PY - 1999/12

Y1 - 1999/12

N2 - A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy.

AB - A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy.

KW - Electromyography

KW - Humans

KW - Immunohistochemistry

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Middle Aged

KW - Muscle Contraction/physiology

KW - Muscle, Skeletal/metabolism

KW - Myosin Heavy Chains/biosynthesis

KW - Paraplegia/metabolism

KW - Protein Isoforms/biosynthesis

KW - Spinal Cord Injuries/metabolism

KW - Tibia

U2 - 10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c

DO - 10.1002/(sici)1097-4598(199912)22:12<1731::aid-mus20>3.0.co;2-c

M3 - Journal article

C2 - 10567091

SN - 0148-639X

VL - 22

SP - 1731

EP - 1737

JO - Muscle & Nerve

JF - Muscle & Nerve

IS - 12

ER -

High expression of MHC I in the tibialis anterior muscle of a paraplegic patient

Abstract

Keywords

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