High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis

Caroline Hasselbalch Riley; Vibe Skov; Thomas Stauffer Larsen; Mads Thomassen; Caroline Hasselbalch Riley; Morten K Jensen; Ole Weis Bjerrum; Torben A Kruse

doi:10.1016/j.leukres.2011.03.013

High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis

Caroline Hasselbalch Riley, Vibe Skov, Thomas Stauffer Larsen, Mads Thomassen, Caroline Hasselbalch Riley, Morten K Jensen, Ole Weis Bjerrum, Torben A Kruse

13 Citations (Scopus)

Abstract

Primary myelofibrosis (PMF) is characterized by leukoerythroblastic anemia with circulating immature myeloid cells, including CD34+ cells, progressive splenomegaly and accumulation of connective tissue and neoangiogenesis in the bone marrow. Altered bone marrow stroma and cell adherence account for the egress of CD34+ cells from the bone marrow. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 has been implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of PMF. Accordingly, CEACAMs may play an important role in these processes in patients with myelofibrosis as well. Using a genome-wide approach, several genes of the CEACAM family were found to be deregulated in patients with PMF and related myeloproliferative neoplasms (n=69). In PMF patients, the CEACAM6 and 8 were significantly upregulated (fold change (FC) 12.5 and 14.0, respectively and FDR adjusted p values 7.71×10(-7) and 1.48×10(-5), respectively). The elevated expression of CEACAM genes may reflect clonal myeloid expansion and neutrophil activation being most exaggerated in patients with PMF. Alternatively, the highly elevated gene expression of CEACAM6 and 8 in PMF may be molecular markers of myelofibrotic transformation, implying enhanced proteolytic activity, egress of CD34+ cells into the circulation, and neoangiogenesis.

Original language	English
Journal	Leukemia Research
Volume	35
Issue number	10
Pages (from-to)	1330-4
Number of pages	5
ISSN	0261-474X
DOIs	https://doi.org/10.1016/j.leukres.2011.03.013
Publication status	Published - 2011

Keywords

Aged
Antigens, CD
Antigens, CD34
Biological Markers
Bone Marrow
Case-Control Studies
Cell Adhesion
Cell Adhesion Molecules
Cell Movement
Female
GPI-Linked Proteins
Gene Expression Regulation, Neoplastic
Genome-Wide Association Study
Humans
Inflammation
Male
Middle Aged
Neovascularization, Pathologic
Neutrophil Activation
Oligonucleotide Array Sequence Analysis
Primary Myelofibrosis
T-Lymphocytes

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10.1016/j.leukres.2011.03.013

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@article{c4e75d8ed5774a83bfe6fc9ca947a8b1,

title = "High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis",

abstract = "Primary myelofibrosis (PMF) is characterized by leukoerythroblastic anemia with circulating immature myeloid cells, including CD34+ cells, progressive splenomegaly and accumulation of connective tissue and neoangiogenesis in the bone marrow. Altered bone marrow stroma and cell adherence account for the egress of CD34+ cells from the bone marrow. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 has been implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of PMF. Accordingly, CEACAMs may play an important role in these processes in patients with myelofibrosis as well. Using a genome-wide approach, several genes of the CEACAM family were found to be deregulated in patients with PMF and related myeloproliferative neoplasms (n=69). In PMF patients, the CEACAM6 and 8 were significantly upregulated (fold change (FC) 12.5 and 14.0, respectively and FDR adjusted p values 7.71×10(-7) and 1.48×10(-5), respectively). The elevated expression of CEACAM genes may reflect clonal myeloid expansion and neutrophil activation being most exaggerated in patients with PMF. Alternatively, the highly elevated gene expression of CEACAM6 and 8 in PMF may be molecular markers of myelofibrotic transformation, implying enhanced proteolytic activity, egress of CD34+ cells into the circulation, and neoangiogenesis.",

keywords = "Aged, Antigens, CD, Antigens, CD34, Biological Markers, Bone Marrow, Case-Control Studies, Cell Adhesion, Cell Adhesion Molecules, Cell Movement, Female, GPI-Linked Proteins, Gene Expression Regulation, Neoplastic, Genome-Wide Association Study, Humans, Inflammation, Male, Middle Aged, Neovascularization, Pathologic, Neutrophil Activation, Oligonucleotide Array Sequence Analysis, Primary Myelofibrosis, T-Lymphocytes",

author = "Riley, {Caroline Hasselbalch} and Vibe Skov and Larsen, {Thomas Stauffer} and Mads Thomassen and Riley, {Caroline Hasselbalch} and Jensen, {Morten K} and Bjerrum, {Ole Weis} and Kruse, {Torben A}",

year = "2011",

doi = "10.1016/j.leukres.2011.03.013",

language = "English",

volume = "35",

pages = "1330--4",

journal = "Leukemia Research",

issn = "0261-474X",

publisher = "Pergamon",

number = "10",

}

TY - JOUR

T1 - High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis

AU - Riley, Caroline Hasselbalch

AU - Skov, Vibe

AU - Larsen, Thomas Stauffer

AU - Thomassen, Mads

AU - Riley, Caroline Hasselbalch

AU - Jensen, Morten K

AU - Bjerrum, Ole Weis

AU - Kruse, Torben A

PY - 2011

Y1 - 2011

N2 - Primary myelofibrosis (PMF) is characterized by leukoerythroblastic anemia with circulating immature myeloid cells, including CD34+ cells, progressive splenomegaly and accumulation of connective tissue and neoangiogenesis in the bone marrow. Altered bone marrow stroma and cell adherence account for the egress of CD34+ cells from the bone marrow. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 has been implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of PMF. Accordingly, CEACAMs may play an important role in these processes in patients with myelofibrosis as well. Using a genome-wide approach, several genes of the CEACAM family were found to be deregulated in patients with PMF and related myeloproliferative neoplasms (n=69). In PMF patients, the CEACAM6 and 8 were significantly upregulated (fold change (FC) 12.5 and 14.0, respectively and FDR adjusted p values 7.71×10(-7) and 1.48×10(-5), respectively). The elevated expression of CEACAM genes may reflect clonal myeloid expansion and neutrophil activation being most exaggerated in patients with PMF. Alternatively, the highly elevated gene expression of CEACAM6 and 8 in PMF may be molecular markers of myelofibrotic transformation, implying enhanced proteolytic activity, egress of CD34+ cells into the circulation, and neoangiogenesis.

AB - Primary myelofibrosis (PMF) is characterized by leukoerythroblastic anemia with circulating immature myeloid cells, including CD34+ cells, progressive splenomegaly and accumulation of connective tissue and neoangiogenesis in the bone marrow. Altered bone marrow stroma and cell adherence account for the egress of CD34+ cells from the bone marrow. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 has been implicated in cell adhesion, cellular invasiveness, angiogenesis, and inflammation, which are all key processes in the pathophysiology of PMF. Accordingly, CEACAMs may play an important role in these processes in patients with myelofibrosis as well. Using a genome-wide approach, several genes of the CEACAM family were found to be deregulated in patients with PMF and related myeloproliferative neoplasms (n=69). In PMF patients, the CEACAM6 and 8 were significantly upregulated (fold change (FC) 12.5 and 14.0, respectively and FDR adjusted p values 7.71×10(-7) and 1.48×10(-5), respectively). The elevated expression of CEACAM genes may reflect clonal myeloid expansion and neutrophil activation being most exaggerated in patients with PMF. Alternatively, the highly elevated gene expression of CEACAM6 and 8 in PMF may be molecular markers of myelofibrotic transformation, implying enhanced proteolytic activity, egress of CD34+ cells into the circulation, and neoangiogenesis.

KW - Aged

KW - Antigens, CD

KW - Antigens, CD34

KW - Biological Markers

KW - Bone Marrow

KW - Case-Control Studies

KW - Cell Adhesion

KW - Cell Adhesion Molecules

KW - Cell Movement

KW - Female

KW - GPI-Linked Proteins

KW - Gene Expression Regulation, Neoplastic

KW - Genome-Wide Association Study

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

KW - Neovascularization, Pathologic

KW - Neutrophil Activation

KW - Oligonucleotide Array Sequence Analysis

KW - Primary Myelofibrosis

KW - T-Lymphocytes

U2 - 10.1016/j.leukres.2011.03.013

DO - 10.1016/j.leukres.2011.03.013

M3 - Journal article

C2 - 21470677

SN - 0261-474X

VL - 35

SP - 1330

EP - 1334

JO - Leukemia Research

JF - Leukemia Research

IS - 10

ER -

High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis

Abstract

Keywords

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