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The Capital Region of Denmark - a part of Copenhagen University Hospital
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High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

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  1. Impact analysis of rotavirus vaccination in various geographic regions in Western Europe

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  2. Self-reported immunity and opinions on vaccination of hospital personnel among paediatric healthcare workers in Denmark

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  3. Are refugees arriving in Denmark an under-immunised group for measles? A cross-sectional serology study

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  1. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

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  2. A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine

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  3. Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants

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Malaria during pregnancy is a major cause of intra-uterine growth-retardation and infant death in sub-Saharan Africa. Ideally, this could be prevented by a vaccine delivered before the first pregnancy. Antibodies against domain DBL4ɛ from VAR2CSA has been shown to inhibit adhesion of laboratory isolates to the placental receptor chondroitin sulfate A. In this study, the binding inhibitory efficacy of IgG elicited by two different DBL4ɛ recombinant proteins was tested on a panel of fresh clinical isolates from pregnant women living in Benin and Tanzania. The most promising recombinant protein elicited antibodies with similar efficacy as pooled plasma from immune multi-gravid African women.
Original languageEnglish
JournalVaccine
Volume29
Issue number3
Pages (from-to)437-43
Number of pages7
ISSN0264-410X
DOIs
Publication statusPublished - 10 Jan 2011

    Research areas

  • Antibodies, Protozoan, Antigens, Protozoan, Benin, Cell Adhesion, DNA Repair Enzymes, Erythrocytes, Female, Humans, Immunoglobulin G, Malaria Vaccines, Malaria, Falciparum, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Infectious, Recombinant Proteins, Tanzania, Transcription Factors

ID: 32769219