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High cortisol awakening response is associated with an impairment of the effect of bright light therapy

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@article{7b39b83451474440a2657d2788a5a2ad,
title = "High cortisol awakening response is associated with an impairment of the effect of bright light therapy",
abstract = "OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.",
keywords = "Depressive Disorder, Major, Double-Blind Method, Female, Humans, Hydrocortisone, Male, Middle Aged, Phototherapy, Predictive Value of Tests, Psychometrics, Saliva, Serotonin Uptake Inhibitors, Sertraline, Treatment Failure, Wakefulness",
author = "Martiny, {Klaus Per Juul} and Lunde, {Marianne Anita} and M Und{\'e}n and Dam, {Ole Henrik} and P Bech",
year = "2009",
month = "9",
day = "1",
doi = "10.1111/j.1600-0447.2009.01359.x",
language = "English",
volume = "120",
pages = "196--202",
journal = "Acta Psychiatrica Scandinavica",
issn = "0001-690X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - High cortisol awakening response is associated with an impairment of the effect of bright light therapy

AU - Martiny, Klaus Per Juul

AU - Lunde, Marianne Anita

AU - Undén, M

AU - Dam, Ole Henrik

AU - Bech, P

PY - 2009/9/1

Y1 - 2009/9/1

N2 - OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.

AB - OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.

KW - Depressive Disorder, Major

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Hydrocortisone

KW - Male

KW - Middle Aged

KW - Phototherapy

KW - Predictive Value of Tests

KW - Psychometrics

KW - Saliva

KW - Serotonin Uptake Inhibitors

KW - Sertraline

KW - Treatment Failure

KW - Wakefulness

U2 - 10.1111/j.1600-0447.2009.01359.x

DO - 10.1111/j.1600-0447.2009.01359.x

M3 - Journal article

VL - 120

SP - 196

EP - 202

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 3

ER -

ID: 30976293