High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia

K Schmiegelow; U Lausten Thomsen; A Baruchel; C E Pacheco; Rob Pieters; M S Pombo-de-Oliveira; E W Andersen; Katrine Rostgaard; Helle Hjalgrim; C-H Pui

doi:10.1038/leu.2011.274

High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia

K Schmiegelow, U Lausten Thomsen, A Baruchel, C E Pacheco, Rob Pieters, M S Pombo-de-Oliveira, E W Andersen, Katrine Rostgaard, Helle Hjalgrim, C-H Pui

Department of Paediatrics and Adolescent Medicine

25 Citations (Scopus)

Abstract

Polymorphic genes have been linked to the risk of acute lymphoblastic leukemia (ALL). Surrogate markers for a low burden of early childhood infections are also related to increased risk for developing childhood ALL. It remains uncertain, whether siblings of children with ALL have an increased risk of developing ALL. This international collaboration identified 54 sibships with two (N = 51) or more (N = 3) cases of childhood ALL (ages

Original language	English
Journal	Leukemia
Volume	26
Issue number	4
Pages (from-to)	675-81
Number of pages	7
ISSN	0887-6924
DOIs	https://doi.org/10.1038/leu.2011.274
Publication status	Published - 2012

Keywords

Child, Preschool
Female
Humans
Immunophenotyping
Infant
Leukocyte Count
Male
Oncogene Proteins, Fusion
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Risk Factors

Access to Document

10.1038/leu.2011.274

Cite this

Schmiegelow, K., Lausten Thomsen, U., Baruchel, A., Pacheco, C. E., Pieters, R., Pombo-de-Oliveira, M. S., Andersen, E. W., Rostgaard, K., Hjalgrim, H., & Pui, C.-H. (2012). High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia. Leukemia, 26(4), 675-81. https://doi.org/10.1038/leu.2011.274

Schmiegelow, K, Lausten Thomsen, U, Baruchel, A, Pacheco, CE, Pieters, R, Pombo-de-Oliveira, MS, Andersen, EW, Rostgaard, K, Hjalgrim, H & Pui, C-H 2012, 'High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia', Leukemia, vol. 26, no. 4, pp. 675-81. https://doi.org/10.1038/leu.2011.274

@article{deba7edf9bf14725bdc5d0fc2c375e00,

title = "High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia",

abstract = "Polymorphic genes have been linked to the risk of acute lymphoblastic leukemia (ALL). Surrogate markers for a low burden of early childhood infections are also related to increased risk for developing childhood ALL. It remains uncertain, whether siblings of children with ALL have an increased risk of developing ALL. This international collaboration identified 54 sibships with two (N = 51) or more (N = 3) cases of childhood ALL (ages ",

keywords = "Child, Preschool, Female, Humans, Immunophenotyping, Infant, Leukocyte Count, Male, Oncogene Proteins, Fusion, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Risk Factors",

author = "K Schmiegelow and \{Lausten Thomsen\}, U and A Baruchel and Pacheco, \{C E\} and Rob Pieters and Pombo-de-Oliveira, \{M S\} and Andersen, \{E W\} and Katrine Rostgaard and Helle Hjalgrim and C-H Pui",

year = "2012",

doi = "10.1038/leu.2011.274",

language = "English",

volume = "26",

pages = "675--81",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer Nature",

number = "4",

}

TY - JOUR

T1 - High concordance of subtypes of childhood acute lymphoblastic leukemia within families

T2 - lessons from sibships with multiple cases of leukemia

AU - Schmiegelow, K

AU - Lausten Thomsen, U

AU - Baruchel, A

AU - Pacheco, C E

AU - Pieters, Rob

AU - Pombo-de-Oliveira, M S

AU - Andersen, E W

AU - Rostgaard, Katrine

AU - Hjalgrim, Helle

AU - Pui, C-H

PY - 2012

Y1 - 2012

N2 - Polymorphic genes have been linked to the risk of acute lymphoblastic leukemia (ALL). Surrogate markers for a low burden of early childhood infections are also related to increased risk for developing childhood ALL. It remains uncertain, whether siblings of children with ALL have an increased risk of developing ALL. This international collaboration identified 54 sibships with two (N = 51) or more (N = 3) cases of childhood ALL (ages

AB - Polymorphic genes have been linked to the risk of acute lymphoblastic leukemia (ALL). Surrogate markers for a low burden of early childhood infections are also related to increased risk for developing childhood ALL. It remains uncertain, whether siblings of children with ALL have an increased risk of developing ALL. This international collaboration identified 54 sibships with two (N = 51) or more (N = 3) cases of childhood ALL (ages

KW - Child, Preschool

KW - Female

KW - Humans

KW - Immunophenotyping

KW - Infant

KW - Leukocyte Count

KW - Male

KW - Oncogene Proteins, Fusion

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Risk Factors

UR - https://www.scopus.com/pages/publications/84859651186

U2 - 10.1038/leu.2011.274

DO - 10.1038/leu.2011.274

M3 - Journal article

C2 - 22005784

SN - 0887-6924

VL - 26

SP - 675

EP - 681

JO - Leukemia

JF - Leukemia

IS - 4

ER -

High concordance of subtypes of childhood acute lymphoblastic leukemia within families: lessons from sibships with multiple cases of leukemia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this