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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

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  1. Characteristics influencing expected cognitive performance during hypoglycaemia in type 2 diabetes

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  2. Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

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  3. Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

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  4. Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

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  1. Plasma Cotinine Cutoff for Distinguishing Smokers From Nonsmokers Among Persons Living With HIV

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  2. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

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  3. No association between early maternal HbA1c and offspring birthweight among women without pre-existing diabetes in Greenland

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  4. Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants

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Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11-1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05-1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume108
Pages (from-to)150-154
Number of pages5
ISSN0306-4530
DOIs
Publication statusPublished - Oct 2019

ID: 57848467