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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Hepatotoxicity of amiodarone

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  1. Xamoterol, a new selective beta-1-adrenoceptor partial agonist, in the treatment of postural hypotension

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  2. Is adrenergic betareceptor blockade contraindicated in patients with intermittent claudication?

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  3. The prevalence of secondary hypertension in elderly hypertensive patients

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  4. Localization of aldosterone-producing tumours in primary aldosteronism by adrenal and renal vein catheterization

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  1. Symptoms and biomarkers associated with undiagnosed celiac seropositivity

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  2. Biochemical Diagnosis of Bile Acid Diarrhea: Prospective Comparison With the 75Seleno-Taurohomocholic Acid Test

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  3. Long-term Consequences of Undiagnosed Celiac Seropositivity

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  4. The association of celiac disease and allergic disease in a general adult population

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Amiodarone has proved very effective in the treatment of otherwise resistant cardiac tachyarrhythmias. The use of amiodarone has, however, been limited due to its serious side-effects. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a review of the hepatotoxicity of amiodarone is given. It is concluded that solid evidence exists of hepatic injury due to amiodarone treatment, including steatosis, alterations resembling alcoholic hepatitis, cholestatic hepatitis and micronodular cirrhosis of the liver. Patients receiving amiodarone should be regularly screened with respect to hepatic enzyme levels. Therapy should be discontinued on the suspicion of cholestatic injury or hepatomegaly.
Original languageEnglish
JournalActa Medica Scandinavica
Volume219
Issue number2
Pages (from-to)235-9
Number of pages5
ISSN0001-6101
Publication statusPublished - 1986

    Research areas

  • Aged, Amiodarone, Benzofurans, Cholestasis, Intrahepatic, Humans, Liver Function Tests, Male, Tachycardia

ID: 39697631