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Hepatokines-a novel group of exercise factors

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  2. Training state and fasting-induced PDH regulation in human skeletal muscle

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  3. Effects of training status on PDH regulation in human skeletal muscle during exercise

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  4. Effect of high-fat diet on rat myometrium during pregnancy-isolated myometrial mitochondria are not affected

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  2. Muscle-liver substrate fluxes in exercising humans and potential effects on hepatic metabolism

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  3. Early life exposures to perfluoroalkyl substances in relation to adipokine hormone levels at birth and during childhood

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Regular physical activity not only improves the exercise capacity of the skeletal muscle performing the contractions, but it is beneficial for the whole body. An extensive search for "exercise factors" mediating these beneficial effects has been going on for decades. Particularly skeletal muscle tissue has been investigated as a source of circulating exercise factors, and several myokines have been identified. However, exercise also has an impact on other tissues. The liver is interposed between energy storing and energy utilising tissues and is highly active during exercise, maintaining energy homeostasis. Recently, a novel group of exercise factors-termed hepatokines-has emerged. These proteins (fibroblast growth factor 21, follistatin, angiopoietin-like protein 4, heat shock protein 72, insulin-like growth factor binding protein 1) are released from the liver and increased in the bloodstream during or in the recovery after an exercise bout. In this narrative review, we evaluate this new group of exercise factors focusing on the regulation and potential function in exercise metabolism and adaptations. These hepatokines may convey some of the beneficial whole-body effects of exercise that could ameliorate metabolic diseases, such as obesity or type 2 diabetes.

Original languageEnglish
JournalPflügers Archiv - European Journal of Physiology
Volume471
Issue number3
Pages (from-to)383-396
Number of pages14
ISSN0031-6768
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • ANGPTL4, Energy metabolism, Exercise, FGF21, Follistatin, Hepatokines, HSP72, IGFBP, Insulin resistance, Liver, Selenoprotein P, Training, Type 2 diabetes

ID: 58189621