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Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations-Role of Carbohydrate and Energy Availability

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  4. Cardiac Autonomic Function is Associated With Myocardial Flow Reserve in Type 1 Diabetes

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  1. Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People

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  2. GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Correction to: Effects of glucagon-like peptide 1 analogs on alcohol intake in alcohol-preferring vervet monkeys

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  4. Effect of the incretin hormones on the endocrine pancreas in end-stage renal disease

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  5. Assessment of Islet Alpha- and Beta-Cell Function

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

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Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated. On the basis of recent experimental evidence, we summarize existing evidence to suggest hepatic insulin clearance as a major and immediate regulator of systemic insulin concentrations responding within days to altered dietary energy and, in particular, carbohydrate intake. Hepatic insulin clearance seems to be closely associated with opposite alterations in hepatic lipid content and glucose production, providing a potential mechanistic link to hepatic insulin sensitivity. The molecular regulation of insulin clearance in the liver is likely to involve changes in insulin binding and receptor internalization in response to the dietary alterations, the molecular mechanisms of which await further research.

Original languageEnglish
JournalDiabetes
Volume67
Issue number11
Pages (from-to)2129-2136
Number of pages8
ISSN0012-1797
DOIs
Publication statusPublished - Nov 2018

ID: 55509161