TY - JOUR
T1 - Hemicrania Continua
T2 - An Update
AU - Al-Khazali, Haidar M
AU - Christensen, Rune Häckert
AU - Lambru, Giorgio
AU - Dodick, David W
AU - Ashina, Håkan
N1 - © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/10
Y1 - 2023/10
N2 - PURPOSE OF REVIEW: Hemicrania Continua (HC) is a rare and disabling primary headache disorder that is characterized by persistent, unilateral headache with ipsilateral, cranial autonomic symptoms and restlessness or agitation. The diagnosis requires patients to experience an absolute response to therapeutic doses of indomethacin.RECENT FINDINGS: HC is diagnosed in in about 1.8% of adult patients who were evaluated for headache in tertiary care services, albeit this estimate should be interpreted with caution. The most prevalent accompanying symptoms appear to be lacrimation, conjunctival injection and restlessness or agitation. However, the available literature is limited by methodologic issues, and the current diagnostic criteria lack clarity on what defines absolute response to indomethacin. More rigorous studies are thus needed to improve our understanding of HC which, in turn, will facilitate better disease management in clinical practice. Here, we provide a comprehensive overview of HC, including its epidemiology, clinical presentation, diagnostic evaluation, and management.
AB - PURPOSE OF REVIEW: Hemicrania Continua (HC) is a rare and disabling primary headache disorder that is characterized by persistent, unilateral headache with ipsilateral, cranial autonomic symptoms and restlessness or agitation. The diagnosis requires patients to experience an absolute response to therapeutic doses of indomethacin.RECENT FINDINGS: HC is diagnosed in in about 1.8% of adult patients who were evaluated for headache in tertiary care services, albeit this estimate should be interpreted with caution. The most prevalent accompanying symptoms appear to be lacrimation, conjunctival injection and restlessness or agitation. However, the available literature is limited by methodologic issues, and the current diagnostic criteria lack clarity on what defines absolute response to indomethacin. More rigorous studies are thus needed to improve our understanding of HC which, in turn, will facilitate better disease management in clinical practice. Here, we provide a comprehensive overview of HC, including its epidemiology, clinical presentation, diagnostic evaluation, and management.
KW - Clinical Characteristics
KW - Epidemiology
KW - Headache
KW - Hemicrania Continua
KW - Indomethacin
KW - Trigeminal Autonomic Cephalalgias
UR - http://www.scopus.com/inward/record.url?scp=85167653332&partnerID=8YFLogxK
U2 - 10.1007/s11916-023-01156-9
DO - 10.1007/s11916-023-01156-9
M3 - Review
C2 - 37566220
SN - 1531-3433
VL - 27
SP - 543
EP - 550
JO - Current Pain and Headache Reports
JF - Current Pain and Headache Reports
IS - 10
ER -