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HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Identification of two distinct pathways of human myelopoiesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. BloodSpot: a database of healthy and malignant haematopoiesis updated with purified and single cell mRNA sequencing profiles

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Leukemogenic nucleophosmin mutation disrupts the transcription factor hub regulating granulo-monocytic fates

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Differences in Cell Cycle Status Underlie Transcriptional Heterogeneity in the HSC Compartment

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The HemaExplorer (http://servers.binf.ku.dk/hemaexplorer) is a curated database of processed mRNA Gene expression profiles (GEPs) that provides an easy display of gene expression in haematopoietic cells. HemaExplorer contains GEPs derived from mouse/human haematopoietic stem and progenitor cells as well as from more differentiated cell types. Moreover, data from distinct subtypes of human acute myeloid leukemia is included in the database allowing researchers to directly compare gene expression of leukemic cells with those of their closest normal counterpart. Normalization and batch correction lead to full integrity of the data in the database. The HemaExplorer has comprehensive visualization interface that can make it useful as a daily tool for biologists and cancer researchers to assess the expression patterns of genes encountered in research or literature. HemaExplorer is relevant for all research within the fields of leukemia, immunology, cell differentiation and the biology of the haematopoietic system.
Original languageEnglish
JournalNucleic Acids Research
Volume41
Issue numberDatabase issue
Pages (from-to)D1034-9
ISSN0305-1048
DOIs
Publication statusPublished - 2013

ID: 36840252