Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Heavy-load resistance exercise during chemotherapy in physically inactive breast cancer survivors at risk for lymphedema: a randomized trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Meet the Acta Oncologica editorial board

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence and survival of hypopharyngeal cancer: a Danish Nation-Wide Study from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. An investigative expansion of a competing risk model for first failure site in locally advanced non-small cell lung cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dual-energy material decomposition for cone-beam computed tomography in image-guided radiotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. NTCP model validation method for DAHANCA patient selection of protons versus photons in head and neck cancer radiotherapy

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Due to long-standing concerns that heavy-load lifting could increase the risk of developing lymphedema, breast cancer survivors have been advised to refrain from resistance exercise with heavy loads. This study prospectively evaluated the effect of heavy-load resistance exercise on lymphedema development in women receiving chemotherapy for breast cancer. Material and Methods: Physically inactive women receiving adjuvant chemotherapy for breast cancer (n = 153) were randomized to a HIGH (supervised, multimodal exercise including heavy-load resistance exercise: 85-90% 1 repetition maximum [RM], three sets of 5-8 repetitions) versus LOW (pedometer and one-on-one consultations) 12-week intervention. Outcomes (baseline, 12 and 39 weeks) included lymphedema status (extracellular fluid [bioimpedance spectroscopy] and inter-arm volume % difference [dual-energy X-ray absorptiometry], lymphedema symptoms [numeric rating scale 0-10]), upper-extremity strength (1 RM), and quality of life domains (EORTC- BR23). Linear mixed models were used to evaluate equivalence between groups for lymphedema outcomes (equivalence margins for L-Dex, % difference and symptoms scale: ±5, ±3% and ±1, respectively). Superiority analysis was conducted for muscle strength and quality of life domains. Results: Postintervention equivalence between groups was found for extracellular fluid (0.4; 90% CI -2.5 to 3.2) and symptoms of heaviness (-0.2; -0.6 to 0.2), tightness (-0.1; -0.8 to 0.6) and swelling (0.2; -0.4 to 0.8). Nonequivalence was found for inter-arm volume % difference (-3.5%; -17.3 to 10.3) and pain (-0.7; -1.3 to 0), favoring HIGH. Strength gains were superior in the HIGH versus LOW group (3 kg; 1 to 5, p < .05). Further, clinically relevant reductions in breast (-11; -15 to -7) and arm (-6; -10 to -1) symptoms were found in the HIGH group. Conclusion: Findings suggest that physically inactive breast cancer survivors can benefit from supervised heavy-load resistance exercise during chemotherapy without increasing lymphedema risk. Trial registration: ISRCTN13816000.

Original languageEnglish
JournalActa oncologica (Stockholm, Sweden)
Volume58
Issue number12
Pages (from-to)1667-1675
Number of pages9
ISSN0284-186X
DOIs
Publication statusPublished - Dec 2019

ID: 57729284